Genetic Risk Score Predicts Late-Life Cognitive Impairment
Joint Authors
Wollam, Mariegold E.
Saxton, Judith A.
Morrow, Lisa
Snitz, Beth
Fowler, Nicole R.
Suever Erickson, Barbara L.
Roecklein, Kathryn A.
Weinstein, Andrea M.
Erickson, Kirk I.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-23
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Introduction.
A family history of Alzheimer’s disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood.
Methods.
In a sample of 95 older adults (Mean age = 75.1, 64.2% female), we constructed a genetic risk score based on the accumulation of risk alleles in BDNF, COMT, and APOE.
A neuropsychological evaluation and consensus determined cognitive status (44 nonimpaired, 51 impaired).
Logistic regression was performed to determine whether the genetic risk score predicted cognitive impairment above and beyond that associated with each gene.
Results.
An increased genetic risk score was associated with a nearly 4-fold increased risk of cognitive impairment (OR = 3.824, P = .013) when including the individual gene polymorphisms as covariates in the model.
Discussion.
A risk score combining multiple genetic influences may be more useful in predicting late-life cognitive impairment than individual polymorphisms.
American Psychological Association (APA)
Wollam, Mariegold E.& Weinstein, Andrea M.& Saxton, Judith A.& Morrow, Lisa& Snitz, Beth& Fowler, Nicole R.…[et al.]. 2015. Genetic Risk Score Predicts Late-Life Cognitive Impairment. Journal of Aging Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067265
Modern Language Association (MLA)
Wollam, Mariegold E.…[et al.]. Genetic Risk Score Predicts Late-Life Cognitive Impairment. Journal of Aging Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067265
American Medical Association (AMA)
Wollam, Mariegold E.& Weinstein, Andrea M.& Saxton, Judith A.& Morrow, Lisa& Snitz, Beth& Fowler, Nicole R.…[et al.]. Genetic Risk Score Predicts Late-Life Cognitive Impairment. Journal of Aging Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067265