Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft)
Joint Authors
Chaudhary, Narendra Kumar
Mishra, Parashuram
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Two new metal complexes of general formula M(Haαft)2 [M = NiII and CuII] of asymmetrical Schiff base ligand (HL = Haαft) derived from amoxicillin and α-formylthiophene have been prepared and characterized by various physicochemical and spectral techniques.
Molar conductance measurement indicates nonelectrolytic nature of the metal complexes.
FT-IR spectral study reveals the ligation of metal ions at two different nitrogen [NN] donor sites of Haαft.
FT-IR and electronic absorption spectral evidences suggest distorted tetrahedral and square planar geometry for CuII and NiII complexes, respectively.
The structure optimization by molecular mechanics (MM) force field calculation through ArgusLab 4.0.1 version software also supports the concerned geometry of the complexes.
The cell dimensions as suggested by XRPD study, a (6.753 Å), b (13.904 Å), c (20.122 Å), α (142.76°), β (106.580°), and γ (72.4343°) for CuII and a (24.2547 Å), b (6.6371 Å), c (5.5047 Å) (α = β = γ = 90°) for NiII complexes, are in good agreement with their triclinic and orthorhombic crystal systems.
Particle size calculation by Scherrer’s formula indicates nanocrystalline nature of the complexes.
The antibacterial sensitivity study suggests promising activities of Haαft (Ligand) and M(Haαft)2 complexes against four clinical pathogenic bacteria, namely, E.
coli, P.
vulgaris, P.
aeruginosa, and S.
aureus, though being less active than the standard drug amikacin.
American Psychological Association (APA)
Chaudhary, Narendra Kumar& Mishra, Parashuram. 2015. Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft). Journal of Chemistry،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067319
Modern Language Association (MLA)
Chaudhary, Narendra Kumar& Mishra, Parashuram. Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft). Journal of Chemistry No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1067319
American Medical Association (AMA)
Chaudhary, Narendra Kumar& Mishra, Parashuram. Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft). Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067319