Towards the Application of Atorvastatin to Intensify Proapoptotic Potential of Conventional Antileukemic Agents In Vitro
Joint Authors
Smolewski, Piotr
Cebula-Obrzut, Barbara
Żołnierczyk, Jolanta D.
Kaźmierczuk, Arleta
Hikisz, Paweł
Wawrzyniak, Ewa
Błoński, Jerzy Z.
Misiewicz, Małgorzata
Robak, Paweł
Kiliańska, Zofia M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
It has been previously revealed that statins used at high concentrations display antileukemic potential towards chronic lymphocytic leukemia (CLL) cells.
However, their usage alone in clinical practice may be limited due to possible side effects of high doses of these drugs.
On the other hand, combined treatment of leukemia with statins and the conventional chemotherapeutics is questionable because of unknown influence of the first on the standard treatment results.
This study has revealed that in vitro atorvastatin increases the proapoptotic potential of cladribine and mafosfamide in CLL cells isolated from peripheral blood of patients.
Moreover, a preincubation with the above statin sensitizes leukemic cells to CM-induced apoptosis even at small concentrations of the drug.
The usage of atorvastatin together with or followed by the conventional chemotherapy should be considered as therapeutic option for the treatment for this leukemia.
Interestingly, CM-resistant patients might have the biggest benefits from atorvastatin administration.
American Psychological Association (APA)
Żołnierczyk, Jolanta D.& Kaźmierczuk, Arleta& Hikisz, Paweł& Cebula-Obrzut, Barbara& Wawrzyniak, Ewa& Błoński, Jerzy Z.…[et al.]. 2015. Towards the Application of Atorvastatin to Intensify Proapoptotic Potential of Conventional Antileukemic Agents In Vitro. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067327
Modern Language Association (MLA)
Żołnierczyk, Jolanta D.…[et al.]. Towards the Application of Atorvastatin to Intensify Proapoptotic Potential of Conventional Antileukemic Agents In Vitro. Journal of Chemistry No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1067327
American Medical Association (AMA)
Żołnierczyk, Jolanta D.& Kaźmierczuk, Arleta& Hikisz, Paweł& Cebula-Obrzut, Barbara& Wawrzyniak, Ewa& Błoński, Jerzy Z.…[et al.]. Towards the Application of Atorvastatin to Intensify Proapoptotic Potential of Conventional Antileukemic Agents In Vitro. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067327