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Synthesis and Pesticidal Activities of 5-(2-Cyclopropylaminopyrimidin-4-yl)-4-(thiophenyl)thiazole Derivatives
Joint Authors
Bae, In Kyung
Choi, Won-Sik
Nam, Seok-Woo
Kim, Il-Doo
Kim, Seung-Han
Park, Kun-Ho
Park, Eun-Sil
Jeon, Hwang-Ju
Lee, Sung-Eun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Pesticidal activities of 4-[5-(2-cyclopropylaminopyrimidin-4-yl)-4-(4-chloro-2-fluoro-phenyl)thiazol-2-yl]-1-methylpiperidine, designated as Comp I, have been determined against a mosquito larva, Culex pipiens pallens, and a phytopathogenic fungus, Phytophthora capsici.
Comp I was used as the leading compound in this study.
The compounds were synthesized by reacting them with two functional groups, 3-thiophenyl and 2-thiophenyl groups, instead of 4-chloro-2-fluorophenyl group in Comp I.
Other functional groups such as 2-aminothiazole, 2-(1-methylpiperazin-4-yl)thiazole, and 2-(piperazin-4-yl)thiazole were also introduced instead of 2-methylpiperidin-4-yl-thiazole of Comp I.
Compounds designated as XIII-6~XV-7 were newly synthesized and their structures were confirmed by 1H- and 13C-NMR spectroscopy.
Mosquito larvicidal activities of all the synthesized compounds against C.
pipiens pallens were examined and Comp I among them showed the strongest larvicidal activity as 0.513 mM of LC50 value.
The fungicidal activities of all the synthesized compounds against P.
capsici were examined using the whole plant method.
Among the XIII-6~XV-7 chemicals, 5-(2-cyclopropylaminopyrimidin-4-yl)-4-(thiophen-2-yl)thiazol-2-amine (VIII-6) showed the most potent antifungal activity in vivo.
While the EC50 value of the commercial fungicide dimethomorph was 4.26 μM, EC50 of VIII-6 was 0.94 μM.
Therefore, thiazole derivatives can be considered as viable candidates for the control of mosquito larvae and plant diseases.
American Psychological Association (APA)
Choi, Won-Sik& Nam, Seok-Woo& Kim, Il-Doo& Kim, Seung-Han& Park, Kun-Ho& Bae, In Kyung…[et al.]. 2015. Synthesis and Pesticidal Activities of 5-(2-Cyclopropylaminopyrimidin-4-yl)-4-(thiophenyl)thiazole Derivatives. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067367
Modern Language Association (MLA)
Choi, Won-Sik…[et al.]. Synthesis and Pesticidal Activities of 5-(2-Cyclopropylaminopyrimidin-4-yl)-4-(thiophenyl)thiazole Derivatives. Journal of Chemistry No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1067367
American Medical Association (AMA)
Choi, Won-Sik& Nam, Seok-Woo& Kim, Il-Doo& Kim, Seung-Han& Park, Kun-Ho& Bae, In Kyung…[et al.]. Synthesis and Pesticidal Activities of 5-(2-Cyclopropylaminopyrimidin-4-yl)-4-(thiophenyl)thiazole Derivatives. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067367