Microwave-Assisted Synthesis and Antimicrobial Activity of Some Novel Isatin Schiff Bases Linked to Nicotinic Acid via Certain Amino Acid Bridge
Joint Authors
Bhat, Mashooq A.
Naglah, Ahmed M.
Awad, Hassan M.
Amr, Abd El-Galil E.
al-Omar, Mohamed A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The coupling reaction of nicotinic acid with certain L-amino acid methyl esters including valine, leucine, and phenylalanine was done by the use of acid chloride method.
The products were reacted with hydrazine hydrate 99% to give the corresponding hydrazides that were reacted with indoline-2,3-dione (isatin) to get Schiff bases under the application of microwave irradiation technique.
These novel compounds were characterized by means of their FT-IR, 1H NMR, and mass spectral data.
Additionally, the specific optical rotation and elemental analysis were measured.
The in vitro antimicrobial activity of the synthesized compounds was evaluated by agar diffusion method.
The compounds showed a strong antimicrobial inhibitory activity.
Most of the test compounds possessed a broad spectrum of activities having MIC values ranging from 50 µg/mL to 500 µg/mL.
American Psychological Association (APA)
Naglah, Ahmed M.& Awad, Hassan M.& Bhat, Mashooq A.& al-Omar, Mohamed A.& Amr, Abd El-Galil E.. 2015. Microwave-Assisted Synthesis and Antimicrobial Activity of Some Novel Isatin Schiff Bases Linked to Nicotinic Acid via Certain Amino Acid Bridge. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067425
Modern Language Association (MLA)
Naglah, Ahmed M.…[et al.]. Microwave-Assisted Synthesis and Antimicrobial Activity of Some Novel Isatin Schiff Bases Linked to Nicotinic Acid via Certain Amino Acid Bridge. Journal of Chemistry No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067425
American Medical Association (AMA)
Naglah, Ahmed M.& Awad, Hassan M.& Bhat, Mashooq A.& al-Omar, Mohamed A.& Amr, Abd El-Galil E.. Microwave-Assisted Synthesis and Antimicrobial Activity of Some Novel Isatin Schiff Bases Linked to Nicotinic Acid via Certain Amino Acid Bridge. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067425