Synthesis of Water-Soluble Iridium (III)-Containing Nanoparticles for Biological Applications
Joint Authors
Hou, Huanzhi
Sun, Pengfei
Fan, Quli
Lu, Xiaomei
Xue, Cheng
Zhang, Yixue
Tian, Sichao
Huang, Wei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Water-soluble nanoparticles (Ir/PGlc-NP, Ir/β-1,3-glucan-NP) based on water-soluble glycopolymers (PGlc), β-1,3-glucan polysaccharide, and conjugated phosphorescent Ir (III) complexes were successfully synthesized by self-assembly.
The obtained nanoparticles have good spherical morphological characterization with a mean diameter of 50 nm measured by TEM.
Ir/PGlc-NP and Ir/β-1,3-glucan-NP showed the same emission maxima at 565 nm in aqueous solution and both caused effective apoptosis and death of HepG2 and Hela cells after being irradiated at 445 nm for 30 min in vitro.
Fluorescence cellular imaging was conducted by confocal laser scanning microscopy (CLSM) using HepG2 cells as the model cell in which the nanoparticles had successfully entered into the cytoplasm with high brightness.
Furthermore, after injecting the nanoparticles into live mice in vivo, the real-time fluorescence imaging as well as the nanoparticles distribution in organs at 24 hours after administration indicated that these nanoparticles can serve as fluorescent imaging contrast for further biological applications.
American Psychological Association (APA)
Hou, Huanzhi& Sun, Pengfei& Fan, Quli& Lu, Xiaomei& Xue, Cheng& Zhang, Yixue…[et al.]. 2015. Synthesis of Water-Soluble Iridium (III)-Containing Nanoparticles for Biological Applications. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067474
Modern Language Association (MLA)
Hou, Huanzhi…[et al.]. Synthesis of Water-Soluble Iridium (III)-Containing Nanoparticles for Biological Applications. Journal of Chemistry No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067474
American Medical Association (AMA)
Hou, Huanzhi& Sun, Pengfei& Fan, Quli& Lu, Xiaomei& Xue, Cheng& Zhang, Yixue…[et al.]. Synthesis of Water-Soluble Iridium (III)-Containing Nanoparticles for Biological Applications. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067474