![](/images/graphics-bg.png)
Studies on the Protective Effects of Scutellarein against Neuronal Injury by Ischemia through the Analysis of Endogenous Amino Acids and Ca2+ Concentration Together with Ca2+-ATPase Activity
Joint Authors
Tang, Yu-Ping
Duan, Jinao
Zhang, Peng-Xuan
Li, Nian-Guang
Tang, Hao
Dong, Ze-Xi
Gu, Ting
Shi, Qian-Ping
Guo, Jian-Ming
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Scutellarin, which is extracted from the dried plant of Erigeron breviscapus, has been reported to protect the neural injury against excitotoxicity induced by ischemia.
However, there are a few studies on the protective effects of scutellarein, which is the main metabolite of scutellarin in vivo.
Thus, this study investigated the neuroprotective effects of scutellarein on cerebral ischemia/reperfusion in rats by bilateral common carotid artery occlusion (BCCAO) model, through the analysis of endogenous amino acids using HILIC-MS/MS, and evaluation of Ca2+ concentration together with Ca2+-ATPase activity.
The results showed that scutellarein having good protective effects on cerebral ischemia/reperfusion might by decreasing the excitatory amino acids, increasing the inhibitory amino acids, lowing intracellular Ca2+ level, and improving Ca2+-ATPase activity, which suggested that scutellarein might be a promising potent agent for the therapy of ischemic cerebrovascular disease.
American Psychological Association (APA)
Tang, Hao& Dong, Ze-Xi& Gu, Ting& Li, Nian-Guang& Tang, Yu-Ping& Shi, Qian-Ping…[et al.]. 2015. Studies on the Protective Effects of Scutellarein against Neuronal Injury by Ischemia through the Analysis of Endogenous Amino Acids and Ca2+ Concentration Together with Ca2+-ATPase Activity. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067488
Modern Language Association (MLA)
Tang, Hao…[et al.]. Studies on the Protective Effects of Scutellarein against Neuronal Injury by Ischemia through the Analysis of Endogenous Amino Acids and Ca2+ Concentration Together with Ca2+-ATPase Activity. Journal of Chemistry No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067488
American Medical Association (AMA)
Tang, Hao& Dong, Ze-Xi& Gu, Ting& Li, Nian-Guang& Tang, Yu-Ping& Shi, Qian-Ping…[et al.]. Studies on the Protective Effects of Scutellarein against Neuronal Injury by Ischemia through the Analysis of Endogenous Amino Acids and Ca2+ Concentration Together with Ca2+-ATPase Activity. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067488