In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives
Joint Authors
Ali, Niaz
Shoaib, Mohammad
Ali Shah, Syed Wadood
Shah, Ismail
Naveed Umar, Muhammad
Shafiullah, Muhammad
Ayaz, Muhammad
Tahir, Muhammad Nawaz
Akhtar, Sohail
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Free radicals are produced by an important chemical process known as oxidation that in turn initiates chain reactions to damage the cells and originate oxidative stress.
Flavones have got special position in research field of natural and synthetic organic chemistry due to their biological capabilities as antioxidant.
The antioxidants are known to possess extensive biological effects that include antiviral, antibacterial, anti-inflammatory, antithrombotic, and vasodilatory activities.
The simple flavone (F1) and substituted flavone derivatives (F2–F5) have been synthesized from o-hydroxyacetophenone and benzaldehyde derivatives in good yield.
The structures have been established by different spectroscopic techniques like 1H NMR, 13C NMR, IR, and elemental analysis.
Antioxidant profile of these compounds was established using DPPH and H2O2 free radical scavenging assay.
The findings showed that halogenated flavones showed more enzyme inhibitions and antioxidant activities than simple flavones and are potential candidates for the treatment of wide range of diseases.
American Psychological Association (APA)
Shoaib, Mohammad& Ali Shah, Syed Wadood& Ali, Niaz& Shah, Ismail& Naveed Umar, Muhammad& Shafiullah, Muhammad…[et al.]. 2015. In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067493
Modern Language Association (MLA)
Shoaib, Mohammad…[et al.]. In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives. Journal of Chemistry No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067493
American Medical Association (AMA)
Shoaib, Mohammad& Ali Shah, Syed Wadood& Ali, Niaz& Shah, Ismail& Naveed Umar, Muhammad& Shafiullah, Muhammad…[et al.]. In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067493