Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation
Joint Authors
Abdul Qadir, Muhammad
Ahmed, Mahmood
Ahmed, Mahmood
Shafiq, Muhammad Imtiaz
Ata, Sadia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
New amidine and benzene sulfonamide derivatives were developed and structures of the new products were confirmed by elemental and spectral analysis (FT-IR, ESI-MS, 1HNMR, and 13CNMR).
In vitro, developed compounds were screened for their antibacterial and antifungal activities against medically important bacterial strains, namely, S.
aureus, B.
subtilis, and E.
coli, and fungi, namely, A.
flavus, A.
parasiticus, and A.
sp.
The antibacterial and antifungal activities have been determined by measuring MIC values (μg/mL) and zone of inhibitions (mm).
Among the tested compounds, it was found that compounds 3b, 9a, and 9b have most potent activity against S.
aureus, A.
flavus, and A.
parasiticus, respectively, and were found to be more active than sulfamethoxazole and itraconazole with MIC values 40 μg/mL.
In contrast, all the compounds were totally inactive against the A.
sp.
except 10b and 15b to show activity to some extent.
American Psychological Association (APA)
Abdul Qadir, Muhammad& Ahmed, Mahmood& Ahmed, Mahmood& Ata, Sadia& Shafiq, Muhammad Imtiaz. 2015. Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067499
Modern Language Association (MLA)
Abdul Qadir, Muhammad…[et al.]. Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation. Journal of Chemistry No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067499
American Medical Association (AMA)
Abdul Qadir, Muhammad& Ahmed, Mahmood& Ahmed, Mahmood& Ata, Sadia& Shafiq, Muhammad Imtiaz. Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067499
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067499