Anti-Inflammatory Effect of By-Products from Haliotis discus hannai in RAW 264.7 Cells

Abstract EN

Several reports promoted the potential of shellfish due to their ability to act as antioxidant, anti-inflammatory, and antimicrobial agents.

Pacific abalone, Haliotis discus hannai viscera is, reported to possess bioactivities such as antioxidative stress and anti-inflammatory.

In this study, anti-inflammatory potential of mucus-secreting glands from shell-shucking waste of H.

discus hannai was evaluated using RAW 264.7 mouse macrophage cell model.

Results indicated that presence of H.

discus hannai mucosubstance by-products (AM) significantly lowered the nitric oxide (NO) production along the expressional suppression of inflammatory mediators such as cytokines TNF-α, IL-1β, and IL-6 and enzymes iNOS and COX-2.

Also, AM was shown to increase expression of anti-inflammatory response mediator HO-1.

Presence of AM also scavenged the free radicals in vitro.

In conclusion, by-products of H.

discus hannai are suggested to possess notable anti-inflammatory potential which promotes the possibility of utilization as functional food ingredient.