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Synthesis, Anti-Inflammatory, and Analgesic Activities of Derivatives of 4-Hydroxy-2-benzoxazolone
Joint Authors
Zheng, Guangjin
Chen, Tieyu
Peng, Xing
Long, Shengjing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Benzoxazolones are widely distributed in plants and are of increasing interest for a variety of pharmacological properties, such as detoxification, antibacterial, anti-inflammatory, and analgesic activities and tranquilizers (Michaelidou and Hadjipavlou-Litina, 2005; Doğruer et al., 1998).
4-Hydroxy-2-benzoxazolone (HBOA) is one of the major bioactive compounds in traditional Chinese herb drug Acanthus ilicifolius (Peng and Long, 2006) which has obvious anti-inflammatory and analgesic activities (Huo et al., 2004; Mani Senthil Kumar et al., 2008; Babu et al., 2001).
In this research, we used 2-nitroresorcinol as starting material to prepare HBOA with a novel “one-pot-way.” Derivatives of HBOA TC-2∼TC-4 were obtained via electrophilic reagents and reacted with corresponding primary amines to afford Schiff Base derivatives TC-5∼TC-10 for further study.
Anti-inflammatory and analgesic activities of those derivatives were determined by using carrageenan-induced rat paw edema test.
The analgesic activities of the derivatives were determined by the hot-plate test.
American Psychological Association (APA)
Zheng, Guangjin& Chen, Tieyu& Peng, Xing& Long, Shengjing. 2015. Synthesis, Anti-Inflammatory, and Analgesic Activities of Derivatives of 4-Hydroxy-2-benzoxazolone. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1067509
Modern Language Association (MLA)
Zheng, Guangjin…[et al.]. Synthesis, Anti-Inflammatory, and Analgesic Activities of Derivatives of 4-Hydroxy-2-benzoxazolone. Journal of Chemistry No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1067509
American Medical Association (AMA)
Zheng, Guangjin& Chen, Tieyu& Peng, Xing& Long, Shengjing. Synthesis, Anti-Inflammatory, and Analgesic Activities of Derivatives of 4-Hydroxy-2-benzoxazolone. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1067509
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067509