Derivative Spectrophotometric Methods for the Analysis and Stability Studies of Colistin Sulphate
Joint Authors
Mutasim Elimam, Mohammed
Wagiealla Shantier, Shaza
Ahmed Gadkariem, Elrasheed
Awadalla Mohamed, Magdi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Simple spectrophotometric methods were developed for the quantitative determination of colistin sulphate in bulk and dosage forms.
The methods were based on the measurement of first and second derivative spectra of colistin sulphate at 298 nm and 318 nm, respectively.
Beer’s law was obeyed in the concentration range 800–4000 IU/mL with good correlation coefficient (not less than 0.998) for both methods.
The developed first derivative spectrophotometric method was then selected to study the degradation behavior of colistin sulphate in alkaline media at different temperatures as the second derivative method failed to give reproducible results for the stability study.
The pH-rate profile indicates a first-order dependence of the degradation rate on [OH−] at pH ranging between 8 and 11.
The obtained results for the photochemical study reflected photostability of colistin sulphate.
American Psychological Association (APA)
Mutasim Elimam, Mohammed& Wagiealla Shantier, Shaza& Ahmed Gadkariem, Elrasheed& Awadalla Mohamed, Magdi. 2015. Derivative Spectrophotometric Methods for the Analysis and Stability Studies of Colistin Sulphate. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1067549
Modern Language Association (MLA)
Mutasim Elimam, Mohammed…[et al.]. Derivative Spectrophotometric Methods for the Analysis and Stability Studies of Colistin Sulphate. Journal of Chemistry No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1067549
American Medical Association (AMA)
Mutasim Elimam, Mohammed& Wagiealla Shantier, Shaza& Ahmed Gadkariem, Elrasheed& Awadalla Mohamed, Magdi. Derivative Spectrophotometric Methods for the Analysis and Stability Studies of Colistin Sulphate. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1067549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067549