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Synthesis and In Vitro Biological Evaluation of Aminonaphthoquinones and Benzo[b]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compounds
Joint Authors
Onul, Nihal
Tuyun, Amaç Fatih
Bayrak, Nilüfer
Yıldırım, Hatice
Mataraci Kara, Emel
Ozbek Celik, Berna
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A series of 2-arylamino-3-chloro-1,4-naphthoquinone derivatives (3a–h) by the reaction of 2,3-dichloro-1,4-naphthoquinone with aryl amines (2a–h) and benzo[b]phenazine-6,11-dione derivatives (4a–c) by the treatment of 2-arylamino-3-chloro-1,4-naphthoquinone derivatives (3a–h) with sodium azide were synthesized and tested for their in vitro antibacterial and antifungal activities.
The results suggest that compounds 3d and 3g had potent antifungal activity against Candida albicans (MIC = 78.12 μg/mL).
All synthesized compounds (3a–h, 4a–c) possessed activity against E.
faecalis with MIC values of between 312.5 and 1250 μg/mL.
Benzo[b]phenazine-6,11-dione derivatives (4a–c) were mostly active against Gram-positive bacteria.
The structures of the new members of the series were established on the basis of their spectral properties (IR, 1H NMR, 13C NMR, and mass spectrometry).
American Psychological Association (APA)
Tuyun, Amaç Fatih& Bayrak, Nilüfer& Yıldırım, Hatice& Onul, Nihal& Mataraci Kara, Emel& Ozbek Celik, Berna. 2015. Synthesis and In Vitro Biological Evaluation of Aminonaphthoquinones and Benzo[b]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compounds. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067561
Modern Language Association (MLA)
Tuyun, Amaç Fatih…[et al.]. Synthesis and In Vitro Biological Evaluation of Aminonaphthoquinones and Benzo[b]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compounds. Journal of Chemistry No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067561
American Medical Association (AMA)
Tuyun, Amaç Fatih& Bayrak, Nilüfer& Yıldırım, Hatice& Onul, Nihal& Mataraci Kara, Emel& Ozbek Celik, Berna. Synthesis and In Vitro Biological Evaluation of Aminonaphthoquinones and Benzo[b]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compounds. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067561