Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives
Joint Authors
Ghabbour, Hazem A.
Hozzein, Wael N.
Wadaan, Mohammad A. M.
Khattab, Sherine N.
Fun, Hoong-Kun
El-Faham, Ayman
Siddiqui, M. Rafiq H.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Three series of isatin derivatives [3-hydrazino, 3-thiosemicarbazino, and 3-imino carboxylic acid derivatives] were synthesized employing microwave irradiation.
The prepared compounds were characterized by FT-IR, NMR, elemental analysis, and X-ray crystallography for derivatives 5b.
The synthesized compounds were screened for antimicrobial activity against selected bacteria and fungi.
The results revealed that the N-alkyl isatin derivatives were biologically active with different spectrums activity.
Most of the 3-hydrazino and 3-thiosemicarbazino isatin derivatives were biologically inactive and generally the active derivatives showed weak to moderate activity mainly against Gram-positive bacteria.
The imino isatin carboxylic acid derivatives (2-[4-(1-benzyl-5-bromo-2-oxoindolin-3-ylideneamino) phenyl]acetic acid, 5d) showed promising activity against all tested Gram-positive bacteria and against fungal pathogens.
American Psychological Association (APA)
El-Faham, Ayman& Hozzein, Wael N.& Wadaan, Mohammad A. M.& Khattab, Sherine N.& Ghabbour, Hazem A.& Fun, Hoong-Kun…[et al.]. 2015. Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067602
Modern Language Association (MLA)
El-Faham, Ayman…[et al.]. Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives. Journal of Chemistry No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067602
American Medical Association (AMA)
El-Faham, Ayman& Hozzein, Wael N.& Wadaan, Mohammad A. M.& Khattab, Sherine N.& Ghabbour, Hazem A.& Fun, Hoong-Kun…[et al.]. Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067602