In Vitro Antitumor Activity of a Keggin Vanadium-Substituted Polyoxomolybdate and Its ctDNA Binding Properties
Joint Authors
Qi, Wen
Qin, Ying
Qi, Yanfei
Guo, Li
Li, Juan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A Keggin vanadium-substituted polyoxomolybdate, K5PMo10V2O40 (PMo10V2), has been synthesized and it’s antitumor effect against Hela cells was investigated.
The calf thymus DNA (ctDNA) binding ability of PMo10V2 was also evaluated by UV-Vis absorption spectra and fluorescence spectra.
The identity and high purity of PMo10V2 was confirmed by elemental analysis and IR analysis.
And the antitumor activity test of PMo10V2 was carried out on Hela cancer cells line by MTT assay.
The results of MTT assay show that PMo10V2 significantly reduced the viability of Hela cells in a dose-dependent manner and exhibited stronger inhibitory activity against Hela cells at an IC50 of 800 μg/mL, which is more effective than the positive control, 5-Fu ( P < 0.05 ) .
The results of the UV-Vis absorption spectra and fluorescence spectra indicated the groove or outside stacking binding between PMo10V2 and ctDNA.
These results show that the antitumor activity of PMo10V2 may be caused by the interactions between DNA and PMo10V2.
American Psychological Association (APA)
Qi, Wen& Qin, Ying& Qi, Yanfei& Guo, Li& Li, Juan. 2015. In Vitro Antitumor Activity of a Keggin Vanadium-Substituted Polyoxomolybdate and Its ctDNA Binding Properties. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067618
Modern Language Association (MLA)
Qi, Wen…[et al.]. In Vitro Antitumor Activity of a Keggin Vanadium-Substituted Polyoxomolybdate and Its ctDNA Binding Properties. Journal of Chemistry No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1067618
American Medical Association (AMA)
Qi, Wen& Qin, Ying& Qi, Yanfei& Guo, Li& Li, Juan. In Vitro Antitumor Activity of a Keggin Vanadium-Substituted Polyoxomolybdate and Its ctDNA Binding Properties. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067618