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Development and Validation of a Simple and Selective Analytical HPLC Method for the Quantification of Oxaliplatin
Joint Authors
Cunha-Filho, Marcilio S. S.
Matos, Breno Noronha
Oliveira, Paula Martins de
Reis, Thaiene Avila
Gratieri, Taís
Gelfuso, Guilherme Martins
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Considering that currently published oxaliplatin (OXPt) analytical methods require complex procedures and equipment, the objective of this paper was to present the validation of a simple, rapid, precise, and specific isocratic HPLC method for quantification of OXPt.
Such method will be essential during the future development of innovative, topical drug formulations for the treatment of mucosal and skin cancers.
Validated method demonstrated OXPt separation without interference from the solvents or polymers with the most relevance for developing of bioadhesive pharmaceutical drug carries (chitosan and poloxamer).
Method was linear ( r > 0.999 ) over studied OXPt concentration range (0.5–15.0 µg/mL) with acceptable precision and accuracy.
Limit of detection (LOD) and limit of quantification (LOQ) were 0.099 µg/mL and 0.331 µg/mL, respectively.
American Psychological Association (APA)
Matos, Breno Noronha& Oliveira, Paula Martins de& Reis, Thaiene Avila& Gratieri, Taís& Cunha-Filho, Marcilio S. S.& Gelfuso, Guilherme Martins. 2015. Development and Validation of a Simple and Selective Analytical HPLC Method for the Quantification of Oxaliplatin. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067636
Modern Language Association (MLA)
Matos, Breno Noronha…[et al.]. Development and Validation of a Simple and Selective Analytical HPLC Method for the Quantification of Oxaliplatin. Journal of Chemistry No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1067636
American Medical Association (AMA)
Matos, Breno Noronha& Oliveira, Paula Martins de& Reis, Thaiene Avila& Gratieri, Taís& Cunha-Filho, Marcilio S. S.& Gelfuso, Guilherme Martins. Development and Validation of a Simple and Selective Analytical HPLC Method for the Quantification of Oxaliplatin. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067636