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Evaluation of Anti-MRSA and Xanthine Oxidase Inhibition Activities of Phenolic Constituents from Plumula nelumbinis
Joint Authors
Ding, Xiao
Ouyang, Ming-An
Shen, Yuan-Shuai
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Isolation of metabolites from Plumula nelumbinis led to the discovery of eleven compounds, including six flavonoids and five phenolderivatives.
Their structures have been determined on the basis of chemical and spectroscopic data.
Most of them, such as compounds 1, 4, 6, 8, and 10, have shown inhibitory activity against hospital-acquired methicillin-resistant Staphylococcus aureus (HA-MRSA).
MICs of compound 8 against SA-200195 and SA-300150 were 2 μg/mL and 8 μg/mL, respectively.
And the antioxidant activity of isolated compounds was determined by checking the scavenging activity against three different radicals: 2,2-diphenyl-1-picrydrazyl (DPPH) radical, hydroxyl radical ( O H ∙ ), and superoxide anion ( O 2 ∙ - ), as well as xanthine oxidase inhibition.
All flavonoids showed strong antioxidant activity.
And compound 6 displayed the highest inhibitory effect against xanthine oxidase with IC50 value of 8.2 μg/mL.
American Psychological Association (APA)
Ding, Xiao& Ouyang, Ming-An& Shen, Yuan-Shuai. 2015. Evaluation of Anti-MRSA and Xanthine Oxidase Inhibition Activities of Phenolic Constituents from Plumula nelumbinis. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067641
Modern Language Association (MLA)
Ding, Xiao…[et al.]. Evaluation of Anti-MRSA and Xanthine Oxidase Inhibition Activities of Phenolic Constituents from Plumula nelumbinis. Journal of Chemistry No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1067641
American Medical Association (AMA)
Ding, Xiao& Ouyang, Ming-An& Shen, Yuan-Shuai. Evaluation of Anti-MRSA and Xanthine Oxidase Inhibition Activities of Phenolic Constituents from Plumula nelumbinis. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067641
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067641