Layer-by-Layer Assembly of Polysaccharides and 6,10-Ionene for Separation of Nitrogen-Containing Pharmaceuticals and Their Enantiorecognition by Capillary Electrophoresis
Joint Authors
Ioutsi, Anna
Shapovalova, Elena
Prokhorova, Aleksandra
Shpigun, Oleg
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Two silica capillaries modified layer-by-layer with 6,10-ionene and N-(3-sulfo-3-carboxy)-propionylchitosan (SCPC) and with 6,10-ionene and dextran sulfate (DS) were prepared and investigated.
Dynamic coating of the capillary efficiently reduces the adsorption of the background electrolyte, sample matrix components, and analytes on its inner wall.
Such coatings effect good reproducibility and sensitivity of determination.
We demonstrate that separation of betablockers, calcium channel blockers, alpha-adrenergic agonists, H1-blockers, and diuretics was the most efficient and rapid separation with a capillary modified with dextran sulfate.
Tetrahydrozoline, carbinoxamine, and furacilin, which are commonly employed as treatments for allergic rhinitis, were identified in human urea.
Their concentrations, independently verified by HPLC, were found to be 5.3±0.8, 6.6±0.5, and 0.9±0.2 μg mL−1, with LOD=0.07, 0.03, 0.10 μg mL−1, and LOQ=1.0, 0.8, 0.6 μg mL−1, respectively.
American Psychological Association (APA)
Ioutsi, Anna& Shapovalova, Elena& Prokhorova, Aleksandra& Shpigun, Oleg. 2015. Layer-by-Layer Assembly of Polysaccharides and 6,10-Ionene for Separation of Nitrogen-Containing Pharmaceuticals and Their Enantiorecognition by Capillary Electrophoresis. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067647
Modern Language Association (MLA)
Ioutsi, Anna…[et al.]. Layer-by-Layer Assembly of Polysaccharides and 6,10-Ionene for Separation of Nitrogen-Containing Pharmaceuticals and Their Enantiorecognition by Capillary Electrophoresis. Journal of Chemistry No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1067647
American Medical Association (AMA)
Ioutsi, Anna& Shapovalova, Elena& Prokhorova, Aleksandra& Shpigun, Oleg. Layer-by-Layer Assembly of Polysaccharides and 6,10-Ionene for Separation of Nitrogen-Containing Pharmaceuticals and Their Enantiorecognition by Capillary Electrophoresis. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067647
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067647