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Stereoselective Separation and Acute Toxicity of Tau-Fluvalinate to Zebrafish
Joint Authors
Jia, Qi
Xu, Nana
Mu, Pengqian
Wang, Bo
Yang, Shuming
Qiu, Jing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Tau-fluvalinate (TFLV) is one of the most potent chiral synthetic pyrethroids to control a wide range of pests in agricultural fields, especially in apiary.
In this study, two stereoisomers of TFLV were fully separated by high-performance liquid chromatography (HPLC) with a semipreparative chiral column using cellulose-tris(3,5-dimethylphenylcarbamate) as chiral stationary phase and n-hexane and 2-propanol (96/4, v/v) as mobile phase at a flow rate of 2.5 mL min−1.
The (+)-stereoisomer was first eluted by detecting with an optical rotation detector.
After obtaining pure single stereoisomer of TFLV, acute toxicities of each isomer and TFLV standard to zebrafish were evaluated.
The results showed that the (+)-stereoisomer exhibited 273.4 times higher toxicity than the (−)-stereoisomer and 6.7 times higher than TFLV standard, according to their LC50 values at 96 h after exposure.
This indicates that the toxicity of TFLV mainly originates from (+)-stereoisomer.
These results are very helpful to prepare single stereoisomer of chiral pesticides and evaluate their different toxicological effects to aquatic organisms.
American Psychological Association (APA)
Jia, Qi& Xu, Nana& Mu, Pengqian& Wang, Bo& Yang, Shuming& Qiu, Jing. 2015. Stereoselective Separation and Acute Toxicity of Tau-Fluvalinate to Zebrafish. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1067701
Modern Language Association (MLA)
Jia, Qi…[et al.]. Stereoselective Separation and Acute Toxicity of Tau-Fluvalinate to Zebrafish. Journal of Chemistry No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1067701
American Medical Association (AMA)
Jia, Qi& Xu, Nana& Mu, Pengqian& Wang, Bo& Yang, Shuming& Qiu, Jing. Stereoselective Separation and Acute Toxicity of Tau-Fluvalinate to Zebrafish. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1067701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067701