Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions
Joint Authors
Susan, Md. Abu Bin Hasan
Begum, Ferdousi
Mollah, M. Yousuf A.
Rahman, M. Muhibur
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Kinetics of the acid hydrolysis of bromazepam (Bz) has been investigated in micelles, reverse micelles, and microemulcions of cetyltrimethylammonium bromide (CTAB) by spectrophotometric method.
The rate of the acid hydrolysis of Bz was found to be enhanced both below and above the critical micelle concentration (CMC) of CTAB in aqueous solution.
The pseudo-first-order rate constant (k′) shows an initial decrease for both low and high H+ concentrations.
With further increase in [CTAB], at low [H+], the k′ attains an almost constant value, while, at high [H+], the k′ passes through a maximum and then decreases.
The kinetic data for catalysis by micelles of CTAB was interpreted with the pseudophase ion exchange (PIE) model.
In CTAB/cyclohexane/1-butanol/water microemulsions, as the water to surfactant ratio (wo) increases, the physicochemical properties and droplet sizes of microemulsions significantly change and distinct changes in reaction environment can be marked.
The rate of the hydrolysis reaction exhibits excellent correlation with the physicochemical properties and droplet sizes of the microemulsions and reverse micelles of CTAB.
At [H+] = 0.001 M, in reverse micelles and microemulsions of CTAB, the k′ of the acid hydrolysis of Bz decreases sharply followed by a slight increase with increasing wo.
American Psychological Association (APA)
Begum, Ferdousi& Mollah, M. Yousuf A.& Rahman, M. Muhibur& Susan, Md. Abu Bin Hasan. 2015. Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067716
Modern Language Association (MLA)
Begum, Ferdousi…[et al.]. Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions. Journal of Chemistry No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067716
American Medical Association (AMA)
Begum, Ferdousi& Mollah, M. Yousuf A.& Rahman, M. Muhibur& Susan, Md. Abu Bin Hasan. Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067716