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Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives
Joint Authors
Ramli, Youssef
Essassi, El Mokhtar
El Fal, Mohammed
Zerzouf, Abdelfettah
Talbaoui, Ahmed
Bakri, Youssef
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields.
These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR, 13C, IR, and MS).
The antibacterial activity of the synthesized products was studied using bacterial strains: Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa.
Compounds having an ethyl group showed the best activity with MIC value of 31.25 µg/mL against Staphylococcus aureus and Streptococcus fasciens.
American Psychological Association (APA)
El Fal, Mohammed& Ramli, Youssef& Zerzouf, Abdelfettah& Talbaoui, Ahmed& Bakri, Youssef& Essassi, El Mokhtar. 2015. Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067734
Modern Language Association (MLA)
El Fal, Mohammed…[et al.]. Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives. Journal of Chemistry No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1067734
American Medical Association (AMA)
El Fal, Mohammed& Ramli, Youssef& Zerzouf, Abdelfettah& Talbaoui, Ahmed& Bakri, Youssef& Essassi, El Mokhtar. Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067734