Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test
Joint Authors
Berhane, Feven
Fite, Alemu
Daboul, Nour
Al-Janabi, Wissam
Msallaty, Zaher
Caruso, Michael
Lewis, Monique K.
Yi, Zhengping
Diamond, Michael P.
Seyoum, Berhane
Abou-Samra, Abdul B.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Insulin resistance, which plays a central role in the pathogenesis of type 2 diabetes (T2D), is an early indicator that heralds the occurrence of T2D.
It is imperative to understand the metabolic changes that occur at the cellular level in the early stages of insulin resistance.
The objective of this study was to determine the pattern of circulating lactate levels during oral glucose tolerance test (OGTT) and hyperinsulinemic euglycemic clamp (HIEC) study in normal nondiabetic subjects.
Lactate and glycerol were determined every 30 minutes during OGTT and HIEC on 22 participants.
Lactate progressively increased throughout the HIEC study period ( P < 0.001 ).
Participants with BMI < 30 had significantly higher mean M-values compared to those with BMI ≥ 30 at baseline ( P < 0.05 ).
This trend also continued throughout the OGTT.
In addition, those with impaired glucose tolerance test (IGT) had significantly higher mean lactate levels compared to those with normal glucose tolerance ( P < 0.001 ).
In conclusion, we found that lactate increased during HIEC study, which is a state of hyperinsulinemia similar to the metabolic milieu seen during the early stages in the development of T2D.
American Psychological Association (APA)
Berhane, Feven& Fite, Alemu& Daboul, Nour& Al-Janabi, Wissam& Msallaty, Zaher& Caruso, Michael…[et al.]. 2015. Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067828
Modern Language Association (MLA)
Berhane, Feven…[et al.]. Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test. Journal of Diabetes Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067828
American Medical Association (AMA)
Berhane, Feven& Fite, Alemu& Daboul, Nour& Al-Janabi, Wissam& Msallaty, Zaher& Caruso, Michael…[et al.]. Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067828