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Triglyceride High-Density Lipoprotein Ratios Predict Glycemia-Lowering in Response to Insulin Sensitizing Drugs in Type 2 Diabetes: A Post Hoc Analysis of the BARI 2D
Joint Authors
Zonszein, Joel
Lombardero, Manuel
Ismail-Beigi, Faramarz
Palumbo, Pasquale
Foucher, Suzy
Groenewoud, Yolanda
Cushing, Gary
Wajchenberg, Bernardo
Genuth, Saul
Brooks, Maria Mori
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Glycemic management is central in prevention of small vessel and cardiovascular complications in type 2 diabetes.
With the plethora of newer medications and recommendations for a patient centered approach, more information is necessary to match the proper drug to each patient.
We showed that BARI 2D, a five-year trial designed to compare two different glycemic treatment strategies, was suitable for assessing different responses according to different phenotypic characteristics.
Treatment with insulin sensitizing medications such as thiazolidinediones and metformin was more effective in improving glycemic control, particularly in the more insulin resistant patient, when compared to the insulin provision strategy using insulin and or sulfonylureas.
Triglyceride and high density lipoprotein ratio (TG/HDL-cholesterol ratio) was found to be a readily available and practical biomarker that helps to identify the insulin resistant patient.
These results support the concept that not all medications for glycemic control work the same in all patients.
Thus, tailored therapy can be done using phenotypic characteristics rather than a “one-size-fits-all approach.”
American Psychological Association (APA)
Zonszein, Joel& Lombardero, Manuel& Ismail-Beigi, Faramarz& Palumbo, Pasquale& Foucher, Suzy& Groenewoud, Yolanda…[et al.]. 2015. Triglyceride High-Density Lipoprotein Ratios Predict Glycemia-Lowering in Response to Insulin Sensitizing Drugs in Type 2 Diabetes: A Post Hoc Analysis of the BARI 2D. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067830
Modern Language Association (MLA)
Zonszein, Joel…[et al.]. Triglyceride High-Density Lipoprotein Ratios Predict Glycemia-Lowering in Response to Insulin Sensitizing Drugs in Type 2 Diabetes: A Post Hoc Analysis of the BARI 2D. Journal of Diabetes Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1067830
American Medical Association (AMA)
Zonszein, Joel& Lombardero, Manuel& Ismail-Beigi, Faramarz& Palumbo, Pasquale& Foucher, Suzy& Groenewoud, Yolanda…[et al.]. Triglyceride High-Density Lipoprotein Ratios Predict Glycemia-Lowering in Response to Insulin Sensitizing Drugs in Type 2 Diabetes: A Post Hoc Analysis of the BARI 2D. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067830