Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance
Joint Authors
Łukaszuk, Bartłomiej
Mikłosz, Agnieszka
Górski, Jan
Kurek, Krzysztof
Chabowski, Adrian
Żendzian-Piotrowska, Małgorzata
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nowadays wrong nutritional habits and lack of physical activity give a rich soil for the development of insulin resistance and obesity.
Many researches indicate lipids, especially the one from the sphingolipids class, as the group of molecules heavily implicated in the progress of insulin resistance in skeletal muscle.
Recently, scientists have focused their scrutiny on myriocin, a potent chemical compound that inhibits ceramide (i.e., central hub of sphingolipids signaling pathway) de novo synthesis.
In the present research we evaluated the effects of myriocin application on type 2 diabetes mellitus in three different types of skeletal muscles: (1) slow-oxidative (red gastrocnemius), (2) oxidative-glycolytic (soleus), and (3) glycolytic (white gastrocnemius).
For these reasons the animals were randomly divided into four groups: “control” (C), “myriocin” (M), “high fat diet” (HFD), “high fat diet” (HFD), and “high fat diet + myriocin” (HFD + M).
Our in vivo study demonstrated that ceramide synthesis inhibition reduces intramuscular ceramide, its precursor sphinganine, and its derivatives sphingosine and sphingosine-1-phosphate concentrations.
Moreover, FFA and TG contents were also decreased after myriocin treatment.
Thus, myriocin presents potential therapeutic perspectives with respect to the treatment of insulin resistance and its serious consequences in obese patients.
American Psychological Association (APA)
Kurek, Krzysztof& Mikłosz, Agnieszka& Łukaszuk, Bartłomiej& Chabowski, Adrian& Górski, Jan& Żendzian-Piotrowska, Małgorzata. 2015. Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067835
Modern Language Association (MLA)
Kurek, Krzysztof…[et al.]. Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance. Journal of Diabetes Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1067835
American Medical Association (AMA)
Kurek, Krzysztof& Mikłosz, Agnieszka& Łukaszuk, Bartłomiej& Chabowski, Adrian& Górski, Jan& Żendzian-Piotrowska, Małgorzata. Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067835