![](/images/graphics-bg.png)
Timed Bromocriptine-QR Therapy Reduces Progression of Cardiovascular Disease and Dysglycemia in Subjects with Well-Controlled Type 2 Diabetes Mellitus
Joint Authors
Cincotta, A. H.
Chamarthi, Bindu
Gaziano, J. Michael
Blonde, Lawrence
Scranton, Richard E.
Ezrokhi, Michael
Rutty, Dean
Vinik, Aaron I.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Type 2 diabetes (T2DM) patients, including those in good glycemic control, have an increased risk of cardiovascular disease (CVD).
Maintaining good glycemic control may reduce long-term CVD risk.
However, other risk factors such as elevated vascular sympathetic tone and/or endothelial dysfunction may be stronger potentiators of CVD.
This study evaluated the impact of bromocriptine-QR, a sympatholytic dopamine D2 receptor agonist, on progression of metabolic disease and CVD in T2DM subjects in good glycemic control (HbA1c ≤7.0%).
Methods.
1834 subjects (1219 bromocriptine-QR; 615 placebo) with baseline HbA1c ≤7.0% derived from the Cycloset Safety Trial (this trial is registered with ClinicalTrials.gov Identifier: NCT00377676), a 12-month, randomized, multicenter, placebo-controlled, double-blind study in T2DM, were evaluated.
Treatment impact upon a prespecified composite CVD endpoint (first myocardial infarction, stroke, coronary revascularization, or hospitalization for angina/congestive heart failure) and the odds of losing glycemic control (HbA1c >7.0% after 52 weeks of therapy) were determined.
Results.
Bromocriptine-QR reduced the CVD endpoint by 48% (intention-to-treat; HR: 0.52 [0.28−0.98]) and 52% (on-treatment analysis; HR: 0.48 [0.24−0.95]).
Bromocriptine-QR also reduced the odds of both losing glycemic control (OR: 0.63 (0.47−0.85), p = 0.002 ) and requiring treatment intensification to maintain HbA1c ≤7.0% (OR: 0.46 (0.31−0.69), p = 0.0002 ).
Conclusions.
Bromocriptine-QR therapy slowed the progression of CVD and metabolic disease in T2DM subjects in good glycemic control.
American Psychological Association (APA)
Chamarthi, Bindu& Gaziano, J. Michael& Blonde, Lawrence& Vinik, Aaron I.& Scranton, Richard E.& Ezrokhi, Michael…[et al.]. 2015. Timed Bromocriptine-QR Therapy Reduces Progression of Cardiovascular Disease and Dysglycemia in Subjects with Well-Controlled Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1067837
Modern Language Association (MLA)
Chamarthi, Bindu…[et al.]. Timed Bromocriptine-QR Therapy Reduces Progression of Cardiovascular Disease and Dysglycemia in Subjects with Well-Controlled Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1067837
American Medical Association (AMA)
Chamarthi, Bindu& Gaziano, J. Michael& Blonde, Lawrence& Vinik, Aaron I.& Scranton, Richard E.& Ezrokhi, Michael…[et al.]. Timed Bromocriptine-QR Therapy Reduces Progression of Cardiovascular Disease and Dysglycemia in Subjects with Well-Controlled Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1067837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067837