Ameliorative Effect of Allopurinol on Vascular Complications of Insulin Resistance
Joint Authors
El-Bassossy, Hany M.
Azhar, Ahmad
Ghareib, Salah A.
Alahdal, Abdulrahman M.
Elberry, Ahmed A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of the current study was to evaluate the possible protective effect of allopurinol (Allo) on experimentally induced insulin resistance (IR) and vascular complications.
Rats were divided into four groups: control, IR, allopurinol-treated IR (IR-Allo), and allopurinol-treated control (Allo).
IR was induced by adding fructose and high fat, high salt diet for 12 weeks.
The results showed that Allo has alleviated the increased level of TNF-α and the systolic, diastolic, mean, and notch pressure observed in IR with no change in pulse pressure.
In addition, Allo decreased the heart rate in the treated group compared to IR rats.
On the other hand, it has no effect on increased levels of insulin, glucose, fructosamine, or body weight gain compared to IR group, while it increased significantly the insulin level and body weight without hyperglycemia in the control group.
Moreover, Allo treatment ameliorated increased level of 4HNE, Ang II, and Ang R1.
In conclusion, the results of the current study show that Allo has a protective effect on vascular complications of IR which may be attributed to the effect of Allo on decreasing the TNF-α, 4HNE, Ang II, and Ang R1 as well as increasing the level of insulin secretion.
American Psychological Association (APA)
El-Bassossy, Hany M.& Elberry, Ahmed A.& Azhar, Ahmad& Ghareib, Salah A.& Alahdal, Abdulrahman M.. 2015. Ameliorative Effect of Allopurinol on Vascular Complications of Insulin Resistance. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067849
Modern Language Association (MLA)
El-Bassossy, Hany M.…[et al.]. Ameliorative Effect of Allopurinol on Vascular Complications of Insulin Resistance. Journal of Diabetes Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067849
American Medical Association (AMA)
El-Bassossy, Hany M.& Elberry, Ahmed A.& Azhar, Ahmad& Ghareib, Salah A.& Alahdal, Abdulrahman M.. Ameliorative Effect of Allopurinol on Vascular Complications of Insulin Resistance. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067849