Comparison of Glomerular Filtration Rate Estimation from Serum Creatinine and Cystatin C in HNF1A-MODY and Other Types of Diabetes
Joint Authors
Klupa, Tomasz
Matejko, Bartlomiej
Malecki, Maciej T.
Szopa, Magdalena
Kapusta, Maria
Koblik, Teresa
Kiec-Wilk, Beata
Borowiec, Maciej
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
We previously showed that in HNF1A-MODY the cystatin C-based glomerular filtration rate (GFR) estimate is higher than the creatinine-based estimate.
Currently, we aimed to replicate this finding and verify its clinical significance.
Methods.
The study included 72 patients with HNF1A-MODY, 72 with GCK-MODY, 53 with type 1 diabetes (T1DM), 70 with type 2 diabetes (T2DM), and 65 controls.
Serum creatinine and cystatin C levels were measured.
GFR was calculated from creatinine and cystatin C using the CKD-EPI creatinine equation (eGRF-cr) and CKD-EPI cystatin C equation (eGFR-cys), respectively.
Results.
Cystatin C levels were lower (p<0.001) in the control (0.70±0.13 mg/L), HNF1A (0.75±0.21), and GCK (0.72±0.16 mg/L) groups in comparison to those with either T1DM (0.87±0.15 mg/L) or T2DM (0.9±0.23 mg/L).
Moreover, eGFR-cys was higher than eGRF-cr in HNF1A-MODY, GCK-MODY, and the controls (p=0.004; p=0.003; p<0.0001).
This corresponded to 8.9 mL/min/1.73 m2, 9.7 mL/min/1.73 m2, and 16.9 mL/min/1.73 m2 of difference.
Additionally, T1DM patients had higher eGFR-cr than eGFR-cys (11.6 mL/min/1.73 m2; p=0.0004); no difference occurred in T2DM (p=0.91).
Conclusions.
We confirmed that eGFR-cys values in HNF1A-MODY patients are higher compared to eGFR-cr.
Some other differences were also described in diabetic groups.
However, none of them appears to be clinically relevant.
American Psychological Association (APA)
Szopa, Magdalena& Kapusta, Maria& Matejko, Bartlomiej& Klupa, Tomasz& Koblik, Teresa& Kiec-Wilk, Beata…[et al.]. 2015. Comparison of Glomerular Filtration Rate Estimation from Serum Creatinine and Cystatin C in HNF1A-MODY and Other Types of Diabetes. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1067850
Modern Language Association (MLA)
Szopa, Magdalena…[et al.]. Comparison of Glomerular Filtration Rate Estimation from Serum Creatinine and Cystatin C in HNF1A-MODY and Other Types of Diabetes. Journal of Diabetes Research No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1067850
American Medical Association (AMA)
Szopa, Magdalena& Kapusta, Maria& Matejko, Bartlomiej& Klupa, Tomasz& Koblik, Teresa& Kiec-Wilk, Beata…[et al.]. Comparison of Glomerular Filtration Rate Estimation from Serum Creatinine and Cystatin C in HNF1A-MODY and Other Types of Diabetes. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1067850
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067850