Protective Effects of Scutellarin on Type II Diabetes Mellitus-Induced Testicular Damages Related to Reactive Oxygen SpeciesBcl-2Bax and Reactive Oxygen SpeciesMicrocirculationStaving Pathway in Diabetic Rat
Joint Authors
Long, Lingli
Wang, Jingnan
Lu, Xiaofang
Xu, Yuxia
Zheng, Shuhui
Luo, Canqiao
Li, Yubin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The goal of our study is to evaluate the effect of Scutellarin on type II diabetes-induced testicular disorder and show the mechanism of Scutellarin’s action.
We used streptozotocin and high-fat diet to establish type II diabetic rat model.
TUNEL and haematoxylin and eosin staining were used to evaluate the testicular apoptotic cells and morphologic changes.
Immunohistochemical staining was used to measure the expression level of vascular endothelial growth factor and blood vessel density in testes.
Oxidative stress in testes and epididymis was tested by fluorescence spectrophotometer and ELISA.
The expression of Bcl-2/Bax and blood flow rate in testicular vessels were measured by western blot and Doppler.
Our results for the first time showed that hyperglycemia induced apoptotic cells and morphologic impairments in testes of rats, while administration of Scutellarin can significantly inhibit these damages.
This effect of Scutellarin is controlled by two apoptotic triggers: ROS/Bcl-2/Bax and ROS/microcirculation/starving pathway.
American Psychological Association (APA)
Long, Lingli& Wang, Jingnan& Lu, Xiaofang& Xu, Yuxia& Zheng, Shuhui& Luo, Canqiao…[et al.]. 2015. Protective Effects of Scutellarin on Type II Diabetes Mellitus-Induced Testicular Damages Related to Reactive Oxygen SpeciesBcl-2Bax and Reactive Oxygen SpeciesMicrocirculationStaving Pathway in Diabetic Rat. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067863
Modern Language Association (MLA)
Long, Lingli…[et al.]. Protective Effects of Scutellarin on Type II Diabetes Mellitus-Induced Testicular Damages Related to Reactive Oxygen SpeciesBcl-2Bax and Reactive Oxygen SpeciesMicrocirculationStaving Pathway in Diabetic Rat. Journal of Diabetes Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1067863
American Medical Association (AMA)
Long, Lingli& Wang, Jingnan& Lu, Xiaofang& Xu, Yuxia& Zheng, Shuhui& Luo, Canqiao…[et al.]. Protective Effects of Scutellarin on Type II Diabetes Mellitus-Induced Testicular Damages Related to Reactive Oxygen SpeciesBcl-2Bax and Reactive Oxygen SpeciesMicrocirculationStaving Pathway in Diabetic Rat. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067863