Diabetic Foot Syndrome as a Possible Cardiovascular Marker in Diabetic Patients
Joint Authors
Maida, Carlo
Pinto, Antonio
Tuttolomondo, Antonino
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetic foot ulcerations have been extensively reported as vascular complications of diabetes mellitus associated with a high degree of morbidity and mortality; in fact, some authors showed a higher prevalence of major, previous and new-onset, cardiovascular, and cerebrovascular events in diabetic patients with foot ulcers than in those without these complications.
This is consistent with the fact that in diabetes there is a complex interplay of several variables with inflammatory metabolic disorders and their effect on the cardiovascular system that could explain previous reports of high morbidity and mortality rates in diabetic patients with amputations.
Involvement of inflammatory markers such as IL-6 plasma levels and resistin in diabetic subjects confirmed the pathogenetic issue of the “adipovascular” axis that may contribute to cardiovascular risk in patients with type 2 diabetes.
In patients with diabetic foot, this “adipovascular axis” expression in lower plasma levels of adiponectin and higher plasma levels of IL-6 could be linked to foot ulcers pathogenesis by microvascular and inflammatory mechanisms.
The purpose of this review is to focus on the immune inflammatory features of DFS and its possible role as a marker of cardiovascular risk in diabetes patients.
American Psychological Association (APA)
Tuttolomondo, Antonino& Maida, Carlo& Pinto, Antonio. 2015. Diabetic Foot Syndrome as a Possible Cardiovascular Marker in Diabetic Patients. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067866
Modern Language Association (MLA)
Tuttolomondo, Antonino…[et al.]. Diabetic Foot Syndrome as a Possible Cardiovascular Marker in Diabetic Patients. Journal of Diabetes Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1067866
American Medical Association (AMA)
Tuttolomondo, Antonino& Maida, Carlo& Pinto, Antonio. Diabetic Foot Syndrome as a Possible Cardiovascular Marker in Diabetic Patients. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067866