Association of ATP-Binding Cassette Transporter A1 Gene Polymorphisms in Type 2 Diabetes Mellitus among Malaysians
Joint Authors
Haghvirdizadeh, Polin
Ramachandran, Vasudevan
Etemad, Ali
Heidari, Farzad
Ghodsian, Nooshin
Bin Ismail, Norzian
Ismail, Patimah
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Type 2 diabetes mellitus (T2DM) is a complex polygenic disorder characterized by impaired insulin resistance, insulin secretion, and dysregulation of lipid and protein metabolism with environmental and genetic factors.
ATP-binding cassette transporter A1 (ABCA1) gene polymorphisms are reported as the one of the genetic risk factors for T2DM in various populations with conflicting results.
This study was conducted based on PCR-HRM to determine the frequency of ABCA1 gene by rs2230806 (R219K), rs1800977 (C69T), and rs9282541 (R230C) polymorphisms Malaysian subjects.
Methods.
A total of 164 T2DM and 165 controls were recruited and their genotypes for ABCA1 gene polymorphisms were determined based on the real time high resolution melting analysis.
Results.
There was a significant difference between the subjects in terms of age, BMI, FPG, HbA1c, HDL, LDL, and TG P<0.05.
There was a significant association between HOM of R219K P=0.005, among Malaysian subjects; moreover, allele frequency revealed the significant difference in A allele of R219K P=0.003.
But, there was no significant difference in genotypic and allelic frequencies of C69T and R230C polymorphism.
Conclusion.
R219K polymorphism of ABCA1 gene can be considered as a genetic risk factor for T2DM subjects among Malaysians.
American Psychological Association (APA)
Haghvirdizadeh, Polin& Ramachandran, Vasudevan& Etemad, Ali& Heidari, Farzad& Ghodsian, Nooshin& Bin Ismail, Norzian…[et al.]. 2015. Association of ATP-Binding Cassette Transporter A1 Gene Polymorphisms in Type 2 Diabetes Mellitus among Malaysians. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067871
Modern Language Association (MLA)
Haghvirdizadeh, Polin…[et al.]. Association of ATP-Binding Cassette Transporter A1 Gene Polymorphisms in Type 2 Diabetes Mellitus among Malaysians. Journal of Diabetes Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1067871
American Medical Association (AMA)
Haghvirdizadeh, Polin& Ramachandran, Vasudevan& Etemad, Ali& Heidari, Farzad& Ghodsian, Nooshin& Bin Ismail, Norzian…[et al.]. Association of ATP-Binding Cassette Transporter A1 Gene Polymorphisms in Type 2 Diabetes Mellitus among Malaysians. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067871