New-Onset Diabetes and Glucose Regulation Are Significant Determinants of Left Ventricular Hypertrophy in Renal Transplant Recipients
Joint Authors
Sezer, Siren
Erkmen Uyar, Mehtap
Tutal, Emre
Bal, Zeynep
Guliyev, Orhan
Colak, Turan
Hasdemir, Efe
Haberal, Mehmet
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
New-onset diabetes after transplantation (NODAT) is associated with decreased graft survival and an increased risk for cardiovascular disease.
The objective of this study was to evaluate the risk factors for development of NODAT and its’ relationship with arterial stiffness and left ventricular mass index (LVMI) in kidney transplant recipients.
Methods.
159 kidney transplant recipients were selected from our transplantation center who underwent renal transplantation between years 2007 and 2010.
Results.
Among 159 patients, 57 (32.2%) patients were with NODAT who were significantly older than patients without diabetes (P: 0.0001).
Patients with NODAT had significantly higher pulse wave velocity (PWv) (P: 0.033) and left ventricular mass index LVMI (P: 0.001) compared to patients without NODAT.
Further analysis was done according to LVMI as follows: LVMI > 130 g/m2 (n: 57) and LVMI ≤ 130 g/m2 (n: 102).
We observed higher office systolic and diastolic BP, serum trygliceride, glucose, creatinine, age, and HbA1c (P: 0.0001) levels in patients with LVMI > 130 g/m2.
Linear regression analysis revealed that HbA1c was the major determinant of LVMI (P: 0.026, β: 0.361).
Conclusions.
HbA1c is the major determinant of LVMI, so strict control of serum glucose levels is essential for preventing cardiovascular disease in patients with NODAT.
American Psychological Association (APA)
Sezer, Siren& Erkmen Uyar, Mehtap& Tutal, Emre& Bal, Zeynep& Guliyev, Orhan& Colak, Turan…[et al.]. 2015. New-Onset Diabetes and Glucose Regulation Are Significant Determinants of Left Ventricular Hypertrophy in Renal Transplant Recipients. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067872
Modern Language Association (MLA)
Sezer, Siren…[et al.]. New-Onset Diabetes and Glucose Regulation Are Significant Determinants of Left Ventricular Hypertrophy in Renal Transplant Recipients. Journal of Diabetes Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1067872
American Medical Association (AMA)
Sezer, Siren& Erkmen Uyar, Mehtap& Tutal, Emre& Bal, Zeynep& Guliyev, Orhan& Colak, Turan…[et al.]. New-Onset Diabetes and Glucose Regulation Are Significant Determinants of Left Ventricular Hypertrophy in Renal Transplant Recipients. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067872