Homocysteine, Cortisol, Diabetes Mellitus, and Psychopathology
Joint Authors
Raptis, A. E.
Papageorgiou, C. C.
Tsiotra, Panayoula C.
Raptis, Sotirios A.
Lambadiari, Vaia
Papadimitriou, George N.
Dimitriadis, George
Kontoangelos, Konstantinos A.
Rabavilas, A. D.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
This study investigates the association of homocysteine and cortisol with psychological factors in type 2 diabetic patients.
Method.
Homocysteine, cortisol, and psychological variables were analyzed from 131 diabetic patients.
Psychological factors were assessed with the Eysenck Personality Questionnaire (EPQ), Hostility and Direction of Hostility Questionnaire (HDHQ), the Symptom Checklist 90-R (SCL 90-R), the Zung Self-Rating Depression Scale (ZDRS), and the Maudsley O-C Inventory Questionnaire (MOCI).
Blood samples were taken by measuring homocysteine and cortisol in both subgroups during the initial phase of the study (T0).
One year later (T1), the uncontrolled diabetic patients were reevaluated with the use of the same psychometric instruments and with an identical blood analysis.
Results.
The relation of psychoticism and homocysteine is positive among controlled diabetic patients (P value = 0.006 < 0.05 ) and negative among uncontrolled ones (P value = 0.137).
Higher values of cortisol correspond to lower scores on extraversion subscale ( r p = - 0.223 , P value = 0.010).
Controlled diabetic patients showed a statistically significant negative relationship between homocysteine and the act-out hostility subscale ( r sp = - 0.247 , P = 0.023 ) .
There is a statistically significant relationship between homocysteine and somatization ( r sp = - 0.220 , P = 0.043 ) .
Conclusions.
These findings support the notion that homocysteine and cortisol are related to trait and state psychological factors in patients with diabetes mellitus type 2.
American Psychological Association (APA)
Kontoangelos, Konstantinos A.& Papageorgiou, C. C.& Raptis, A. E.& Tsiotra, Panayoula C.& Lambadiari, Vaia& Papadimitriou, George N.…[et al.]. 2015. Homocysteine, Cortisol, Diabetes Mellitus, and Psychopathology. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067887
Modern Language Association (MLA)
Kontoangelos, Konstantinos A.…[et al.]. Homocysteine, Cortisol, Diabetes Mellitus, and Psychopathology. Journal of Diabetes Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067887
American Medical Association (AMA)
Kontoangelos, Konstantinos A.& Papageorgiou, C. C.& Raptis, A. E.& Tsiotra, Panayoula C.& Lambadiari, Vaia& Papadimitriou, George N.…[et al.]. Homocysteine, Cortisol, Diabetes Mellitus, and Psychopathology. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067887