Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications
Joint Authors
Togliatto, Gabriele
Dentelli, Patrizia
Brizzi, Maria Felice
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Vascular complications are major causes of morbidity and mortality in type 2 diabetes patients.
Mitochondrial reactive oxygen species (ROS) generation and a lack of efficient antioxidant machinery, a result of hyperglycaemia, mainly contribute to this problem.
Although advances in therapy have significantly reduced both morbidity and mortality in diabetic individuals, diabetes-associated vascular complications are still one of the most challenging health problems worldwide.
New healing options are urgently needed as current therapeutics are failing to improve long-term outcomes.
Particular effort has recently been devoted to understanding the functional relationship between chromatin structure regulation and the persistent change in gene expression which is driven by hyperglycaemia and which accounts for long-lasting diabetic complications.
A detailed investigation into epigenetic chromatin modifications in type 2 diabetes is underway.
This will be particularly useful in the design of mechanism-based therapeutics which interfere with long-lasting activating epigenetics and improve patient outcomes.
We herein provide an overview of the most relevant mechanisms that account for hyperglycaemia-induced changes in chromatin structure; the most relevant mechanism is called “metabolic memory.”
American Psychological Association (APA)
Togliatto, Gabriele& Dentelli, Patrizia& Brizzi, Maria Felice. 2015. Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067893
Modern Language Association (MLA)
Togliatto, Gabriele…[et al.]. Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications. Journal of Diabetes Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067893
American Medical Association (AMA)
Togliatto, Gabriele& Dentelli, Patrizia& Brizzi, Maria Felice. Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067893