Associations of Haplotypes Upstream of IRS1 with Insulin Resistance, Type 2 Diabetes, Dyslipidemia, Preclinical Atherosclerosis, and Skeletal Muscle LOC646736 mRNA Levels
Joint Authors
Soyal, Selma M.
Felder, Thomas
Auer, Simon
Oberkofler, Hannes
Iglseder, Bernhard
Paulweber, Bernhard
Dossena, Silvia
Nofziger, Charity
Paulmichl, Markus
Esterbauer, Harald
Krempler, Franz
Patsch, Wolfgang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The genomic region ~500 kb upstream of IRS1 has been implicated in insulin resistance, type 2 diabetes, adverse lipid profile, and cardiovascular risk.
To gain further insight into this chromosomal region, we typed four SNPs in a cross-sectional cohort and subjects with type 2 diabetes recruited from the same geographic region.
From 16 possible haplotypes, 6 haplotypes with frequencies >0.01 were observed.
We identified one haplotype that was protective against insulin resistance (determined by HOMA-IR and fasting plasma insulin levels), type 2 diabetes, an adverse lipid profile, increased C-reactive protein, and asymptomatic atherosclerotic disease (assessed by intima media thickness of the common carotid arteries).
BMI and total adipose tissue mass as well as visceral and subcutaneous adipose tissue mass did not differ between the reference and protective haplotypes.
In 92 subjects, we observed an association of the protective haplotype with higher skeletal muscle mRNA levels of LOC646736, which is located in the same haplotype block as the informative SNPs and is mainly expressed in skeletal muscle, but only at very low levels in liver or adipose tissues.
These data suggest a role for LOC646736 in human insulin resistance and warrant further studies on the functional effects of this locus.
American Psychological Association (APA)
Soyal, Selma M.& Felder, Thomas& Auer, Simon& Oberkofler, Hannes& Iglseder, Bernhard& Paulweber, Bernhard…[et al.]. 2015. Associations of Haplotypes Upstream of IRS1 with Insulin Resistance, Type 2 Diabetes, Dyslipidemia, Preclinical Atherosclerosis, and Skeletal Muscle LOC646736 mRNA Levels. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067903
Modern Language Association (MLA)
Soyal, Selma M.…[et al.]. Associations of Haplotypes Upstream of IRS1 with Insulin Resistance, Type 2 Diabetes, Dyslipidemia, Preclinical Atherosclerosis, and Skeletal Muscle LOC646736 mRNA Levels. Journal of Diabetes Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1067903
American Medical Association (AMA)
Soyal, Selma M.& Felder, Thomas& Auer, Simon& Oberkofler, Hannes& Iglseder, Bernhard& Paulweber, Bernhard…[et al.]. Associations of Haplotypes Upstream of IRS1 with Insulin Resistance, Type 2 Diabetes, Dyslipidemia, Preclinical Atherosclerosis, and Skeletal Muscle LOC646736 mRNA Levels. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067903