Increased Oxidation as an Additional Mechanism Underlying Reduced Clot Permeability and Impaired Fibrinolysis in Type 2 Diabetes
Joint Authors
Lados-Krupa, Anna
Konieczynska, Malgorzata
Chmiel, Artur
Undas, Anetta
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
We sought to investigate whether enhanced oxidation contributes to unfavorable fibrin clot properties in patients with diabetes.
Methods.
We assessed plasma fibrin clot permeation ( K s , a measure of the pore size in fibrin networks) and clot lysis time induced by recombinant tissue plasminogen activator (CLT) in 163 consecutive type 2 diabetic patients (92 men and 71 women) aged 65 ± 8.8 years with a mean glycated hemoglobin (HbA1c) of 6.8%.
We also measured oxidative stress markers, including nitrotyrosine, the soluble form of receptor for advanced glycation end products (sRAGE), 8-iso-prostaglandin F2α (8-iso-PGF2α), oxidized low-density lipoprotein (oxLDL), and advanced glycation end products (AGE).
Results.
There were inverse correlations between K s and nitrotyrosine, sRAGE, 8-iso-PGF2α , and oxLDL.
CLT showed a positive correlation with oxLDL and nitrotyrosine but not with other oxidation markers.
All these associations remained significant for K s after adjustment for fibrinogen, disease duration, and HbA1c (all P < 0.05 ), while oxLDL was the only independent predictor of CLT.
Conclusions.
Our study shows that enhanced oxidative stress adversely affects plasma fibrin clot properties in type 2 diabetic patients, regardless of disease duration and glycemia control.
American Psychological Association (APA)
Lados-Krupa, Anna& Konieczynska, Malgorzata& Chmiel, Artur& Undas, Anetta. 2015. Increased Oxidation as an Additional Mechanism Underlying Reduced Clot Permeability and Impaired Fibrinolysis in Type 2 Diabetes. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067912
Modern Language Association (MLA)
Lados-Krupa, Anna…[et al.]. Increased Oxidation as an Additional Mechanism Underlying Reduced Clot Permeability and Impaired Fibrinolysis in Type 2 Diabetes. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067912
American Medical Association (AMA)
Lados-Krupa, Anna& Konieczynska, Malgorzata& Chmiel, Artur& Undas, Anetta. Increased Oxidation as an Additional Mechanism Underlying Reduced Clot Permeability and Impaired Fibrinolysis in Type 2 Diabetes. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067912