The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

Abstract EN

Background.

The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive.

Methods.

We carried out a meta-analysis that aimed to investigate the association of the rs7903146 variant with plasma lipid levels using electronic database and published studies.

Data was extracted by a standard algorithm.

Dominant, recessive, homozygote, and heterozygote comparison models were utilized.

Results.

24 studies incorporating 52,785 subjects were included in this meta-analysis.

Overall, the minor allele (T) was associated with lower risk for hypertriglyceridemia in subjects with type 2 diabetes (dominant model: SMD = −0.04, 95% CI (−0.08, 0.00), P = 0.048, Pheterogeneity = 0.47; recessive model: SMD = −0.10, 95% CI (−0.18, −0.02), P = 0.01, Pheterogeneity = 0.56).

No association was found between minor (T) allele and plasma TC, LDL-c, or HDL-c levels in subjects with type 2 diabetes or metabolic syndrome (MetS) and no association was found between minor (T) allele and plasma TG levels in nondiabetic subjects.

Conclusions.

Our meta-analysis indicated the association between TCF7L2 rs7903146 polymorphism and low plasma triglyceride (TG) level in subjects with type 2 diabetes.

No association was found between rs7903146 variant and plasma lipids in nondiabetic subjects.