Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial
Joint Authors
Redaelli, Francesca
Ungheri, Saverio
Macedoni, Maddalena
Bosetti, Alessandra
Ferrari, Matteo
Scaramuzza, Andrea
Zuccotti, Gian Vincenzo
Giani, Elisa
Giudici, Valentina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
After evaluating the prevalence of early endothelial dysfunction, as measured by means of reactive hyperemia in adolescents with type 1 diabetes, we started a 6-month, double-blind, randomized trial to test the efficacy of an antioxidant diet (± alpha-lipoic acid supplementation) to improve endothelial dysfunction.
Seventy-one children and adolescents, ages 17 ± 3.9 yrs, with type 1 diabetes since 9.5 ± 5.3 yrs, using intensified insulin therapy, were randomized into 3 arms: (a) antioxidant diet 10.000 ORAC + alpha-lipoic acid; (b) antioxidant diet 10.000 ORAC + placebo; (c) controls.
BMI, blood pressure, fasting lipid profile, HbA1c, insulin requirement, dietary habits, and body composition were determined in each patient.
An antioxidant diet significantly improved endothelial dysfunction when supplemented with alpha-lipoic acid, unlike diet with placebo or controls.
A significant reduction in bolus insulin was also observed.
We speculate that alpha-lipoic acid might have an antioxidant effect in pediatric diabetes patients by reducing insulin.
American Psychological Association (APA)
Scaramuzza, Andrea& Giani, Elisa& Redaelli, Francesca& Ungheri, Saverio& Macedoni, Maddalena& Giudici, Valentina…[et al.]. 2015. Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067917
Modern Language Association (MLA)
Scaramuzza, Andrea…[et al.]. Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial. Journal of Diabetes Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067917
American Medical Association (AMA)
Scaramuzza, Andrea& Giani, Elisa& Redaelli, Francesca& Ungheri, Saverio& Macedoni, Maddalena& Giudici, Valentina…[et al.]. Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067917
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067917