Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats
Joint Authors
Younes, Areej K.
Gordon, Erin E.
Reinking, Benjamin E.
Hu, Shanming
Yao, Jianrong
Kua, Kok L.
Wang, Chunlin
Norris, Andrew W.
Segar, Jeffrey L.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cardiac septal overgrowth complicates 10–40% of births from diabetic mothers, but perplexingly hyperglycemia markers during pregnancy are not reliably predictive.
We thus tested whether fetal exposure to hyperglycemia is sufficient to induce fetal cardiac septal overgrowth even in the absence of systemic maternal diabetes.
To isolate the effects of hyperglycemia, we infused glucose into the blood supply of the left but not right uterine horn in nondiabetic pregnant rats starting on gestational day 19.
After 24 h infusion, right-sided fetuses and dams remained euglycemic while left-sided fetuses were moderately hyperglycemic.
Echocardiograms in utero demonstrated a thickened cardiac septum among left-sided (glucose-exposed, 0.592 ± 0.016 mm) compared to right-sided (control, 0.482 ± 0.016 mm) fetuses.
Myocardial proliferation was increased 1.5 ± 0.2-fold among left-sided compared to right-sided fetuses.
Transcriptional markers of glucose-derived anabolism were not different between sides.
However, left-sided fetuses exhibited higher serum insulin and greater JNK phosphorylation compared to controls.
These results show that hyperglycemic exposure is sufficient to rapidly induce septal overgrowth even in the absence of the myriad other factors of maternal diabetes.
This suggests that even transient spikes in glucose may incite cardiac overgrowth, perhaps explaining the poor clinical correlation of septal hypertrophy with chronic hyperglycemia.
American Psychological Association (APA)
Gordon, Erin E.& Reinking, Benjamin E.& Hu, Shanming& Yao, Jianrong& Kua, Kok L.& Younes, Areej K.…[et al.]. 2015. Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067918
Modern Language Association (MLA)
Gordon, Erin E.…[et al.]. Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats. Journal of Diabetes Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1067918
American Medical Association (AMA)
Gordon, Erin E.& Reinking, Benjamin E.& Hu, Shanming& Yao, Jianrong& Kua, Kok L.& Younes, Areej K.…[et al.]. Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067918
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067918