Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes
Joint Authors
Peterson, Richard G.
Jackson, Charles V.
Zimmerman, Karen
de Winter, Willem
Huebert, Norman
Hansen, Michael K.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Metabolic syndrome and T2D produce significant health and economic issues.
Many available animal models have monogenic leptin pathway mutations that are absent in the human population.
Development of the ZDSD rat model was undertaken to produce a model that expresses polygenic obesity and diabetes with an intact leptin pathway.
A lean ZDF rat with the propensity for beta-cell failure was crossed with a polygenetically obese Crl:CD (SD) rat.
Offspring were selectively inbred for obesity and diabetes for >30 generations.
In the current study, ZDSD rats were followed for 6 months; routine clinical metabolic endpoints were included throughout the study.
In the prediabetic metabolic syndrome phase, ZDSD rats exhibited obesity with increased body fat, hyperglycemia, insulin resistance, dyslipidemia, glucose intolerance, and elevated HbA1c.
As disease progressed to overt diabetes, ZDSD rats demonstrated elevated glucose levels, abnormal oral glucose tolerance, increases in HbA1c levels, reductions in body weight, increased insulin resistance with decreasing insulin levels, and dyslipidemia.
The ZDSD rat develops prediabetic metabolic syndrome and T2D in a manner that mirrors the development of metabolic syndrome and T2D in humans.
ZDSD rats will provide a novel, translational animal model for the study of human metabolic diseases and for the development of new therapies.
American Psychological Association (APA)
Peterson, Richard G.& Jackson, Charles V.& Zimmerman, Karen& de Winter, Willem& Huebert, Norman& Hansen, Michael K.. 2015. Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067923
Modern Language Association (MLA)
Peterson, Richard G.…[et al.]. Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes. Journal of Diabetes Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067923
American Medical Association (AMA)
Peterson, Richard G.& Jackson, Charles V.& Zimmerman, Karen& de Winter, Willem& Huebert, Norman& Hansen, Michael K.. Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067923