Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes
Joint Authors
Kodama, Satoru
Suzuki, Hiroaki
Sato, Akira
Heianza, Yoriko
Saito, Kazumi
Iwasaki, Hitoshi
Kobayashi, Kazuto
Yatoh, Shigeru
Takahashi, Akimitsu
Yahagi, Naoya
Yagyu, Hiroaki
Sone, Hirohito
Shimano, Hitoshi
Fujihara, Kazuya
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
To elucidate the levels of malondialdehyde-modified LDL (MDA-LDL)-related variables for predicting coronary artery stenosis (CAS) by coronary CT angiography (CCTA) in asymptomatic patients with type 2 diabetes (T2DM).
Methods.
Enrolled were 36 Japanese patients with T2DM who underwent CCTA and in whom MDA-LDL levels were measured.
Definition of CAS was luminal narrowing of ≥50%.
Trends through tertiles of each MDA-LDL-related variable were analyzed with a general linear model.
The ability of each MDA-LDL-related variable to predict CAS was compared to areas under the curve (AUCs) in receiver operating characteristic curve (ROC) analysis.
Results.
Seventeen patients had CAS.
Each MDA-LDL-related variable was an independent predictor of CAS ( P = 0.039 for MDALDL, P = 0.013 for MDA-LDL/LDL-C, P = 0.047 for MDA-LDL/HDL-C, and P = 0.013 for (MDA-LDL/LDL-C)/HDL-C).
AUCs of MDA-LDL, MDA-LDL/LDL-C, MDA-LDL/HDL-C, and (MDA-LDL/LDL-C)/HDL-C were 0.675 (95% CI 0.496–0.854), 0.765 (0.602–0.927), 0.752 (0.592–0.913), and 0.799 (0.643–0.955), respectively, for predicting CAS.
Trends throughout the tertiles showed significant associations between MDA-LDL/LDL-C, MDA-LDL/HDL-C, or (MDALDL/LDL-C)/HDL-C and CAS ( P = 0.003 for MDA-LDL/LDL-C, P = 0.042 for MDA-LDL/HDL-C, and P = 0.001 for (MDA-LDL/LDL-C)/HDL-C).
Conclusions.
Data suggest that measurements of MDA-LDL/LDL-C, MDA-LDL/HDLC, and (MDA-LDL/LDL-C)/HDL-C are useful for predicting CAS.
American Psychological Association (APA)
Fujihara, Kazuya& Suzuki, Hiroaki& Sato, Akira& Kodama, Satoru& Heianza, Yoriko& Saito, Kazumi…[et al.]. 2015. Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067929
Modern Language Association (MLA)
Fujihara, Kazuya…[et al.]. Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067929
American Medical Association (AMA)
Fujihara, Kazuya& Suzuki, Hiroaki& Sato, Akira& Kodama, Satoru& Heianza, Yoriko& Saito, Kazumi…[et al.]. Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067929