Association of Plasma Adiponectin and Oxidized Low-Density Lipoprotein with Carotid Intima-Media Thickness in Diabetic Nephropathy
Joint Authors
Papanas, Nikolaos
Manolopoulos, Vangelis G.
Tavridou, Anna
Georgoulidou, Anastasia
Roumeliotis, Athanasios
Roumeliotis, Stefanos
Giannakopoulou, Efstathia
Vargemezis, Vassilis
Passadakis, P. S.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
We sought to determine the association between levels of adiponectin and oxidized low-density lipoprotein (ox-LDL) in patients with diabetic nephropathy as well as their effect on carotid intima-media thickness (cIMT).
Methods.
Adiponectin and ox-LDL were determined in 25 diabetic patients without nephropathy and 94 patients at different stages of diabetic nephropathy including subjects on hemodialysis.
cIMT was measured using real-time B-mode ultrasonography.
Results.
Plasma adiponectin levels increased significantly with severity of diabetic nephropathy ( P = 0.002 ), on the contrary to ox-LDL which decreased with disease severity ( P < 0.001 ).
cIMT was significantly higher at late stages of diabetic nephropathy compared with early stages ( P = 0.022 ).
Adiponectin was a significant negative predictor of ox-LDL levels ( β = - 5.45 , P = 0.023 ), independently of confounding factors.
There was no significant correlation between cIMT and adiponectin or ox-LDL either in the total sample population or according to disease staging.
Cluster analysis showed that patients with the highest cIMT values, highest levels of adiponectin, and lowest levels of ox-LDL were included in one cluster and all assigned to stage 5 of diabetic nephropathy.
Conclusions.
There was no significant association between adiponectin or ox-LDL and cIMT and, therefore, other factors affecting this surrogate marker of cardiovascular disease in diabetic nephropathy should be sought.
American Psychological Association (APA)
Tavridou, Anna& Georgoulidou, Anastasia& Roumeliotis, Athanasios& Roumeliotis, Stefanos& Giannakopoulou, Efstathia& Papanas, Nikolaos…[et al.]. 2015. Association of Plasma Adiponectin and Oxidized Low-Density Lipoprotein with Carotid Intima-Media Thickness in Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067930
Modern Language Association (MLA)
Tavridou, Anna…[et al.]. Association of Plasma Adiponectin and Oxidized Low-Density Lipoprotein with Carotid Intima-Media Thickness in Diabetic Nephropathy. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067930
American Medical Association (AMA)
Tavridou, Anna& Georgoulidou, Anastasia& Roumeliotis, Athanasios& Roumeliotis, Stefanos& Giannakopoulou, Efstathia& Papanas, Nikolaos…[et al.]. Association of Plasma Adiponectin and Oxidized Low-Density Lipoprotein with Carotid Intima-Media Thickness in Diabetic Nephropathy. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067930