Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis
Joint Authors
Nguyen, Phuong Trang
Andraka, Nagore
De Carufel, Carole Anne
Bourgault, Steve
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Type II diabetes mellitus is associated with the deposition of fibrillar aggregates in pancreatic islets.
The major protein component of islet amyloids is the glucomodulatory hormone islet amyloid polypeptide (IAPP).
Islet amyloid fibrils are virtually always associated with several biomolecules, including apolipoprotein E, metals, glycosaminoglycans, and various lipids.
IAPP amyloidogenesis has been originally perceived as a self-assembly homogeneous process in which the inherent aggregation propensity of the peptide and its local concentration constitute the major driving forces to fibrillization.
However, over the last two decades, numerous studies have shown a prominent role of amyloid cofactors in IAPP fibrillogenesis associated with the etiology of type II diabetes.
It is increasingly evident that the biochemical microenvironment in which IAPP amyloid formation occurs and the interactions of the polypeptide with various biomolecules not only modulate the rate and extent of aggregation, but could also remodel the amyloidogenesis process as well as the structure, toxicity, and stability of the resulting fibrils.
American Psychological Association (APA)
Nguyen, Phuong Trang& Andraka, Nagore& De Carufel, Carole Anne& Bourgault, Steve. 2015. Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1067934
Modern Language Association (MLA)
Nguyen, Phuong Trang…[et al.]. Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis. Journal of Diabetes Research No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1067934
American Medical Association (AMA)
Nguyen, Phuong Trang& Andraka, Nagore& De Carufel, Carole Anne& Bourgault, Steve. Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1067934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067934