Dendrobium chrysotoxum Lindl. Alleviates Diabetic Retinopathy by Preventing Retinal Inflammation and Tight Junction Protein Decrease
Joint Authors
Wang, Zheng-Tao
Yu, Zengyang
Gong, Chenyuan
Lu, Bin
Yang, Li
Sheng, Yuchen
Ji, Lili
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic retinopathy (DR) is a serious complication of diabetes mellitus.
This study aimed to observe the alleviation of the ethanol extract of Dendrobium chrysotoxum Lindl.
(DC), a traditional Chinese herbal medicine, on DR and its engaged mechanism.
After DC (30 or 300 mg/kg) was orally administrated, the breakdown of blood retinal barrier (BRB) in streptozotocin- (STZ-) induced diabetic rats was attenuated by DC.
Decreased retinal mRNA expression of tight junction proteins (including occludin and claudin-1) in diabetic rats was also reversed by DC.
Western blot analysis and retinal immunofluorescence staining results further confirmed that DC reversed the decreased expression of occludin and claudin-1 proteins in diabetic rats.
DC reduced the increased retinal mRNA expressions of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor α (TNFα), interleukin- (IL-) 6, and IL-1β in diabetic rats.
In addition, DC alleviated the increased 1 and phosphorylated p65, IκB, and IκB kinase (IKK) in diabetic rats.
DC also reduced the increased serum levels of TNFα, interferon-γ (IFN-γ), IL-6, IL-1β, IL-8, IL-12, IL-2, IL-3, and IL-10 in diabetic rats.
Therefore, DC can alleviate DR by inhibiting retinal inflammation and preventing the decrease of tight junction proteins, such as occludin and claudin-1.
American Psychological Association (APA)
Yu, Zengyang& Gong, Chenyuan& Lu, Bin& Yang, Li& Sheng, Yuchen& Ji, Lili…[et al.]. 2015. Dendrobium chrysotoxum Lindl. Alleviates Diabetic Retinopathy by Preventing Retinal Inflammation and Tight Junction Protein Decrease. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067936
Modern Language Association (MLA)
Yu, Zengyang…[et al.]. Dendrobium chrysotoxum Lindl. Alleviates Diabetic Retinopathy by Preventing Retinal Inflammation and Tight Junction Protein Decrease. Journal of Diabetes Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067936
American Medical Association (AMA)
Yu, Zengyang& Gong, Chenyuan& Lu, Bin& Yang, Li& Sheng, Yuchen& Ji, Lili…[et al.]. Dendrobium chrysotoxum Lindl. Alleviates Diabetic Retinopathy by Preventing Retinal Inflammation and Tight Junction Protein Decrease. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067936