Influence of Melatonin on the Proliferative and Apoptotic Responses of the Prostate under Normal and Hyperglycemic Conditions
Joint Authors
Taboga, Sebastião Roberto
Gobbo, Marina G.
Dizeyi, Nishtman
Abrahamsson, Per-Anders
Bertilsson, Per-Anders
Masitéli, Viviane Sanches
Pytlowanciv, Eloisa Zanin
Góes, Rejane M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-30
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The antitumor properties of melatonin (MLT) are known for prostate cancer cells.
This study investigated whether MLT affects prostate maturation and interferes with tissue injuries induced by diabetes.
MLT was administered to Wistar rats from 5 weeks of age in the drinking water (10 μg/kg b.w.), and diabetes was induced at the 13th week by streptozotocin (4.5 mg/100g b.w., i.p.).
The animals were euthanized in the 14th and 21st weeks.
MLT reduced the immunostained cells for androgen receptor (AR) by 10% in younger rats.
Diabetes decreased cell proliferation and increased apoptosis.
MLT treatment impeded apoptosis p = 0.02 and augmented proliferation p = 0.0008 and PCNA content in prostate following long-term diabetes due to restoration of testosterone levels and expression of melatonin receptor type 1B.
The effect of MLT (500 µM, 5 mM, and 10 mM) on androgen-dependent (22Rv1) and androgen-independent (PC3) cancer cells and human prostate epithelial cells (PNTA1) under normal and hyperglycemic conditions (HG, 450 mg/dL) was analyzed.
Contrary to PNTA1 and 22Rv1 cells, MLT improved the proliferation of PC3 cells in hyperglycemic medium.
The combined data indicated that MLT had proliferative and antiapoptotic effects in prostate cells subjected to HG levels and it seems to involve specific MLT pathways rather than AR.
American Psychological Association (APA)
Gobbo, Marina G.& Dizeyi, Nishtman& Abrahamsson, Per-Anders& Bertilsson, Per-Anders& Masitéli, Viviane Sanches& Pytlowanciv, Eloisa Zanin…[et al.]. 2015. Influence of Melatonin on the Proliferative and Apoptotic Responses of the Prostate under Normal and Hyperglycemic Conditions. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1067939
Modern Language Association (MLA)
Gobbo, Marina G.…[et al.]. Influence of Melatonin on the Proliferative and Apoptotic Responses of the Prostate under Normal and Hyperglycemic Conditions. Journal of Diabetes Research No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1067939
American Medical Association (AMA)
Gobbo, Marina G.& Dizeyi, Nishtman& Abrahamsson, Per-Anders& Bertilsson, Per-Anders& Masitéli, Viviane Sanches& Pytlowanciv, Eloisa Zanin…[et al.]. Influence of Melatonin on the Proliferative and Apoptotic Responses of the Prostate under Normal and Hyperglycemic Conditions. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1067939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067939