Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control
Joint Authors
Kokubun, Eduardo
Hirata, Mario Hiroyuki
Hirata, Rosário Dominguez Crespo
Queiroga, Marcos Roberto
Barbieri, Ricardo Augusto
Ferreira, Sandra Aires
Luchessi, André Ducati
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The influence of cardiorespiratory fitness (VO2max) on anthropometric variables and PPARG mRNA expression was investigated.
Monozygotic twin pairs aged 11–18 years were grouped into discordant (D) and concordant (C) high and low VO2max groups.
VO2max was determined by progressive maximal exercise test on treadmill with gas exchange analysis.
Body mass (BM), BMI, waist circumference (WC), triceps (TR), and subscapular (SB) skinfold thicknesses were measured.
Twins from the discordant group had differences in VO2max values (D-high = 45.9±10.0 versus D-low = 32.4±10.6 mL·kg−1·min−1, P=0.025), while no differences were found in the concordant group (C-high = 42.4±9.2 versus C-low = 38.8±9.8 mL·kg−1·min−1, P=0.952).
In discordant group, VO2max was negatively correlated with TR + SB (r=-0.540, P=0.021) and positively correlated with PPARG expression in leukocytes (r=0.952, P=0.001).
Moreover, PPARG expression was directly correlated with BM (r=0.714, P=0.047) and height (r=0.762, P=0.028).
In concordant twins, VO2max was inversely correlated with BM (r=-0.290, P=0.027), BMI (r=-0.472, P=0.001), WC (r=-0.426, P=0.001), and TR + SB (r=-0.739, P=0.001).
Twins D-high had 1.78-fold greater PPARG expression when compared with twins D-low (P=0.048).
In conclusion, the cardiorespiratory fitness may modulate PPARG expression in childhood and adolescence, independently of the genetic background.
American Psychological Association (APA)
Queiroga, Marcos Roberto& Barbieri, Ricardo Augusto& Ferreira, Sandra Aires& Luchessi, André Ducati& Hirata, Rosário Dominguez Crespo& Hirata, Mario Hiroyuki…[et al.]. 2015. Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067940
Modern Language Association (MLA)
Queiroga, Marcos Roberto…[et al.]. Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control. Journal of Diabetes Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067940
American Medical Association (AMA)
Queiroga, Marcos Roberto& Barbieri, Ricardo Augusto& Ferreira, Sandra Aires& Luchessi, André Ducati& Hirata, Rosário Dominguez Crespo& Hirata, Mario Hiroyuki…[et al.]. Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067940