Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts
Joint Authors
Zhang, Liangqing
Liu, Huimin
Yao, Xinhua
Li, Yalan
Tao, Mingzhe
Wang, Shuang
Lin, Jiefu
Xia, Zhengyuan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The anesthetic propofol confers cardioprotection against myocardial ischemia-reperfusion injury (IRI) by reducing reactive oxygen species (ROS).
However, its cardioprotection on patients is inconsistent.
Similarly, the beneficial effect of tight glycemic control during cardiac surgery in patients has recently been questioned.
We postulated that low glucose (LG) may promote ROS formation through enhancing fatty acid (FA) oxidation and unmask propofol cardioprotection during IRI.
Rat hearts were isolated and randomly assigned to be perfused with Krebs-Henseleit solution with glucose at 5.5 mM (LG) or 8 mM (G) in the absence or presence of propofol (5 μg/mL) or propofol plus trimetazidine (TMZ).
Hearts were subjected to 35 minutes of ischemia followed by 60 minutes of reperfusion.
Myocardial infarct size (IS) and cardiac CK-MB were significantly higher in LG than in G group (P < 0.05), associated with reduced left ventricular developed pressure and increases in postischemic cardiac contracture.
Cardiac 15-F2t-isoprostane was higher, accompanied with higher cardiac lipid transporter CD36 protein expression in LG.
Propofol reduced IS, improved cardiac function, and reduced CD36 in G but not in LG.
TMZ facilitated propofol cardioprotection in LG.
Therefore, isolated heart with low glucose lost sensitivity to propofol treatment through enhancing FA oxidation and TMZ supplementation restored the sensitivity to propofol.
American Psychological Association (APA)
Yao, Xinhua& Li, Yalan& Tao, Mingzhe& Wang, Shuang& Zhang, Liangqing& Lin, Jiefu…[et al.]. 2015. Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067954
Modern Language Association (MLA)
Yao, Xinhua…[et al.]. Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts. Journal of Diabetes Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067954
American Medical Association (AMA)
Yao, Xinhua& Li, Yalan& Tao, Mingzhe& Wang, Shuang& Zhang, Liangqing& Lin, Jiefu…[et al.]. Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067954