Recent Advances in Dipeptidyl-Peptidase-4 Inhibition Therapy: Lessons from the Bench and Clinical Trials
Joint Authors
Zhong, Jixin
Gong, Quan
Goud, Aditya
Srinivasamaharaj, Srividya
Rajagopalan, Sanjay
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
DPP4 inhibitors (DPP4i) are a class of newly developed antidiabetic drugs which preserve incretin hormones and promote postprandial insulin secretion.
Although the cardiovascular effect of DPP4 inhibition has been substantially studied, the exact role of DPP4 in cardiovascular disease especially in humans remains elusive.
Previous small studies and meta-analyses have suggested a benefit in both surrogate outcomes and cardiovascular events for these agents.
However, there was growing evidence in recent years questioning the cardioprotective effect of DPP4i.
Further, a signal of heart failure hospitalization in a recent large scale clinical trial SAVOR-TIMI 53 has called into question the safety of these agents and their utility in the treatment of cardiovascular disease.
In this review, we will revisit the physiologic function of DPP4 and discuss its role in cardiometabolic disease based on recent experimental and clinical studies.
American Psychological Association (APA)
Zhong, Jixin& Gong, Quan& Goud, Aditya& Srinivasamaharaj, Srividya& Rajagopalan, Sanjay. 2015. Recent Advances in Dipeptidyl-Peptidase-4 Inhibition Therapy: Lessons from the Bench and Clinical Trials. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1067957
Modern Language Association (MLA)
Zhong, Jixin…[et al.]. Recent Advances in Dipeptidyl-Peptidase-4 Inhibition Therapy: Lessons from the Bench and Clinical Trials. Journal of Diabetes Research No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1067957
American Medical Association (AMA)
Zhong, Jixin& Gong, Quan& Goud, Aditya& Srinivasamaharaj, Srividya& Rajagopalan, Sanjay. Recent Advances in Dipeptidyl-Peptidase-4 Inhibition Therapy: Lessons from the Bench and Clinical Trials. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1067957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067957