The Relationship between Serum 25-Hydroxy Vitamin D and Insulin Sensitivity and β-Cell Function in Newly Diagnosed Type 2 Diabetes
Joint Authors
Yang, Tao
Fu, Qi
Li, Yanyun
Tang, Wei
Gao, Yuan
Wu, Xinchi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of this study was to investigate the relationship between serum 25-hydroxy vitamin D (25-OHD) and insulin sensitivity and β-cell function in newly diagnosed type 2 diabetes.
395 newly diagnosed type 2 diabetes patients were enrolled in this study.
Venous blood samples were collected at 0 min, 30 min, and 120 min of OGTT to measure serum glucose and insulin.
Matsuda ISI and HOMA-IR were used to determine insulin sensitivity.
The ratio of 0–120 min area under curve of insulin to glucose (insulin release index, INSR) was calculated as surrogate index of β-cell insulin secretion function.
The products of insulin secretion indices multiplied by Matsuda insulin sensitivity index were used as disposition indices.
Patients were divided into three groups according to tertiles (T1, T2, and T3) of 25-OHD concentration.
There was significant difference among three groups for HOMA-IR, Matsuda ISI, and INSR.
HOMA-IR, Matsuda ISI, INSR, and DI were undifferentiated among three groups in male patients.
But HOMA-IR, Matsuda ISI, and INSR were significantly different among three groups in female patients after being adjusted by confounding factors.
In conclusion, serum 25-OHD is associated with insulin sensitivity and β-cell function for female newly diagnosed type 2 diabetes patients, and the association is ambiguous in males.
American Psychological Association (APA)
Gao, Yuan& Wu, Xinchi& Fu, Qi& Li, Yanyun& Yang, Tao& Tang, Wei. 2015. The Relationship between Serum 25-Hydroxy Vitamin D and Insulin Sensitivity and β-Cell Function in Newly Diagnosed Type 2 Diabetes. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1067963
Modern Language Association (MLA)
Gao, Yuan…[et al.]. The Relationship between Serum 25-Hydroxy Vitamin D and Insulin Sensitivity and β-Cell Function in Newly Diagnosed Type 2 Diabetes. Journal of Diabetes Research No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1067963
American Medical Association (AMA)
Gao, Yuan& Wu, Xinchi& Fu, Qi& Li, Yanyun& Yang, Tao& Tang, Wei. The Relationship between Serum 25-Hydroxy Vitamin D and Insulin Sensitivity and β-Cell Function in Newly Diagnosed Type 2 Diabetes. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1067963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067963