Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis
Joint Authors
Adya, Raghu
Tan, Bee K.
Randeva, Harpal S.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Obesity is a major health burden with an increased risk of cardiovascular morbidity and mortality.
Endothelial dysfunction is pivotal to the development of cardiovascular disease (CVD).
In relation to this, adipose tissue secreted factors termed “adipokines” have been reported to modulate endothelial dysfunction.
In this review, we focus on two of the most abundant circulating adipokines, that is, leptin and adiponectin, in the development of endothelial dysfunction.
Leptin has been documented to influence a multitude of organ systems, that is, central nervous system (appetite regulation, satiety factor) and cardiovascular system (endothelial dysfunction leading to atherosclerosis).
Adiponectin, circulating at a much higher concentration, exists in different molecular weight forms, essentially made up of the collagenous fraction and a globular domain, the latter being investigated minimally for its involvement in proinflammatory processes including activation of NF-κβ and endothelial adhesion molecules.
The opposing actions of the two forms of adiponectin in endothelial cells have been recently demonstrated.
Additionally, a local and systemic change to multimeric forms of adiponectin has gained importance.
Thus detailed investigations on the potential interplay between these adipokines would likely result in better understanding of the missing links connecting CVD, adipokines, and obesity.
American Psychological Association (APA)
Adya, Raghu& Tan, Bee K.& Randeva, Harpal S.. 2015. Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067966
Modern Language Association (MLA)
Adya, Raghu…[et al.]. Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis. Journal of Diabetes Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1067966
American Medical Association (AMA)
Adya, Raghu& Tan, Bee K.& Randeva, Harpal S.. Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067966