Updating Experimental Models of Diabetic Cardiomyopathy
Joint Authors
Lorenzo, O.
Fuentes-Antrás, J.
Egido, Jesus
Gómez-Hernández, A.
Tuñón, J.
Picatoste, B.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-20
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Diabetic cardiomyopathy entails a serious cardiac dysfunction induced by alterations in structure and contractility of the myocardium.
This pathology is initiated by changes in energy substrates and occurs in the absence of atherothrombosis, hypertension, or other cardiomyopathies.
Inflammation, hypertrophy, fibrosis, steatosis, and apoptosis in the myocardium have been studied in numerous diabetic experimental models in animals, mostly rodents.
Type I and type II diabetes were induced by genetic manipulation, pancreatic toxins, and fat and sweet diets, and animals recapitulate the main features of human diabetes and related cardiomyopathy.
In this review we update and discuss the main experimental models of diabetic cardiomyopathy, analysing the associated metabolic, structural, and functional abnormalities, and including current tools for detection of these responses.
Also, novel experimental models based on genetic modifications of specific related genes have been discussed.
The study of specific pathways or factors responsible for cardiac failures may be useful to design new pharmacological strategies for diabetic patients.
American Psychological Association (APA)
Fuentes-Antrás, J.& Picatoste, B.& Gómez-Hernández, A.& Egido, Jesus& Tuñón, J.& Lorenzo, O.. 2015. Updating Experimental Models of Diabetic Cardiomyopathy. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1067968
Modern Language Association (MLA)
Fuentes-Antrás, J.…[et al.]. Updating Experimental Models of Diabetic Cardiomyopathy. Journal of Diabetes Research No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1067968
American Medical Association (AMA)
Fuentes-Antrás, J.& Picatoste, B.& Gómez-Hernández, A.& Egido, Jesus& Tuñón, J.& Lorenzo, O.. Updating Experimental Models of Diabetic Cardiomyopathy. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1067968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067968